词条 | Milatuzumab |
释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 458284030 | image = | type = mab | mab_type = mab | source = zu/o | target = CD74 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 899796-83-9 | ATC_prefix = none | ATC_suffix = | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 2OP4E0GC6V | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D08944 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = none | C=6518 | H=10066 | N=1758 | O=2020 | S=40 | molecular_weight = 146.7 kg/mol }}Milatuzumab (or hLL1) is an anti-CD74[1] humanized monoclonal antibody for the treatment of multiple myeloma non-Hodgkin’s lymphoma and chronic lymphocytic leukemia.[2][3][4][5] The drug is the first anti-CD74 antibody that has entered into human testing and is currently being studied for the treatment of multiple myeloma. Milatuzumab has received orphan drug designation from the Food and Drug Administration in the United States for the treatment of multiple myeloma and chronic lymphocytic leukemia. Milatuzumab was developed by Immunomedics, Inc, (Morris Plains NJ USA). CD74{{Contradicts other|date=November 2015|1=CD74}}{{Refimprove section|date=November 2015}}CD74 is present on a variety of hematological tumors and even on some solid cancers. It is present in limited amounts in normal tissues but widely found in leukemias, lymphomas and the vast majority of multiple myeloma cases.{{cn|date=November 2015}} CD74 is involved in a cell-to-cell communication pathway that is critical for survival.{{cn|date=November 2015}} When CD74 is blocked by milatuzumab, it can lead to cell death. CD74 is an attractive target for a drug conjugate because of its rapid internalizing property.{{cn|date=November 2015}} In preclinical studies with human lymphomas and myelomas, both naked Milatuzumab and the Milatuzumab conjugated with doxorubicin,[6] an antibody-drug conjugate or ADC, have demonstrated anti-lymphoma activity in-vivo. Antibody-drug ConjugatesIMMU-110
References1. ^CD74: a new candidate target for the immunotherapy of B-cell neoplasms. R. Stein, M.J. Mattes, T.M. Cardillo, H.J. Hansen, C.H. Chang, J. Burton, S. Govindan, D.M. Goldenberg. Clin Cancer Res 13:5556s-5563s, 2007. {{Monoclonals for tumors}}2. ^Combination anti-CD74 (Milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma. L. Alinari, B. Yu, B.A. Christian, F. Yan, J. Shin, R. Lapalombella, E. Hertlein, M.E. Lustberg, C. Quinion, X. Zhang, G. Lozanski, N. Muthusamy, M. Praetorius-Ibba, O.A. O'Connor, D.M. Goldenberg, J.C. Byrd, K.A. Blum, R.A. Baiocchi. Blood 117:4530-4541, 2011. 3. ^A Phase I study of Milatuzumab, a humanized anti-CD74 antibody, and Veltuzumab, a humanized anti-CD20 antibody, in patients with relapsed and refractory B-cell non-Hodgkin's lymphoma. B. Christian, L. Alinari, C.T. Earl, E. Wilding, C. Quinion, M. Lustberg, D.M. Benson, Jr., J.A. Jones, J.C. Byrd, W.A. Wegener, D.M. Goldenberg, R.A. Baiocchi, K.A. Blum. Blood 116:Abstract 2788, 2010. 4. ^TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner. I. Binsky, F. Lantner, V. Grabovsky, N. Harpaz, L. Shvidel, A. Berrebi, D.M. Goldenberg, L. Leng, R. Bucala, R. Alon, M. Haran, I. Shachar. J Immunol 184:4761-4769, 2010. 5. ^Dose-escalation trial of Milatuzumab (humanized anti-CD74 monoclonal antibody) in multiple myeloma. J.L. Kaufman, R. Niesvizky, E.A. Stadtmauer, A. Chanan-Khan, D. Siegel, H. Horne, N. Teoh, W. A. Wegener, D. M. Goldenberg. J Clin Oncol 27:15s (suppl; abstr 8593), 2009. 6. ^Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. P. Sapra, R. Stein, J. Pickett, Z. Qu, S.V. Govindan, T.M. Cardillo, H.J. Hansen, I.D. Horak, G.L. Griffiths, D.M. Goldenberg. Clin Cancer Res 11:5257-5264, 2005. 7. ^Milatuzumab-Doxorubicin (IMMU-110 / hLL1-dox) Clinical Trials - ADC Review / Journal of Antibody-drug Conjugates 8. ^Immunomedics initiates dosing in milatuzumab-doxorubicin conjugate Phase I/II trial for relapsed multiple myeloma - News Medical and Immunomedics Press Release. |date=16 June 2010 9. ^[https://clinicaltrials.gov/ct2/show/NCT01101594 A Study of hLL1-DOX (Milatuzumab-Doxorubicin Antibody-Drug Conjugate) in Patients With Multiple Myeloma. Clinical Trials ] 2 : Monoclonal antibodies|Experimental cancer drugs |
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