| 词条 | Mitozolomide |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376147382 | IUPAC_name = 3-(2-chloroethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide | image = Mitozolomide.svg | width = 210 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 85622-95-3 | ATC_prefix = none | ATC_suffix = | PubChem = 71766 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = E3U7286V3W | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 435951 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 64805 | C=7 | H=7 | Cl=1 | N=6 | O=2 | molecular_weight = 242.622 g/mol | smiles = NC(=O)c1ncn2C(=O)N(CCCl)\=N/c12 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C7H7ClN6O2/c8-1-2-14-7(16)13-3-10-4(5(9)15)6(13)11-12-14/h3H,1-2H2,(H2,9,15) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = QXYYYPFGTSJXNS-UHFFFAOYSA-N }} Mitozolomide (INN) is an antineoplastic. It is an imidazotetrazine derivative. Development of mitozolomide was discontinued during Phase II clinical trials after it was found to cause severe and unpredictable bone marrow suppression.[1] Temozolomide, which has been in clinical use since 1999, is a less toxic analogue of mitozolomide.[2] References1. ^{{cite journal |vauthors=Fairbairn LJ, Chinnasamy N, Lashford LS, Chinnasamy D, Rafferty JA |title=Enhancing hemopoietic drug resistance: a rationale for reconsidering the clinical use of mitozolomide |journal=Cancer Gene Ther |volume=7 |issue=2 |pages=233–9 |date=February 2000 |pmid=10770631 |url=http://www.nature.com/cgt/journal/v7/n2/pdf/7700120a.pdf |doi=10.1038/sj.cgt.7700120}} {{Chemotherapeutic agents}}{{antineoplastic-drug-stub}}2. ^{{cite journal |vauthors=Newlands ES, Blackledge GR, Slack JA, etal |title=Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856) |journal=Br J Cancer |volume=65 |issue=2 |pages=287–91 |date=February 1992 |pmid=1739631 |pmc=1977719 |doi=10.1038/bjc.1992.57}} 4 : Abandoned drugs|Imidazotetrazines|Carboxamides|Organochlorides |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。