| 释义 |
- References
- Further reading
{{Infobox_gene}}{{Infobox protein family
| Symbol = hNIFK_binding
| Name = FHA Ki67 binding domain of hNIFK
| image = PDB 2aff EBI.jpg
| width =
| caption = the solution structure of the ki67fha/hnifk(226-269)3p complex
| Pfam = PF12196
| Pfam_clan =
| InterPro = IPR021043
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.[1][2]{{PBB_Summary
| section_title =
| summary_text =
}}MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.[3] References1. ^{{cite journal |vauthors=Takagi M, Sueishi M, Saiwaki T, Kametaka A, Yoneda Y | title = A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis | journal = J Biol Chem | volume = 276 | issue = 27 | pages = 25386–91 |date=Jul 2001 | pmid = 11342549 | pmc = | doi = 10.1074/jbc.M102227200 }}
2. ^{{cite web | title = Entrez Gene: MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84365| accessdate = }}
3. ^{{cite journal |vauthors=Byeon IJ, Li H, Song H, Gronenborn AM, Tsai MD | title = Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67 | journal = Nat. Struct. Mol. Biol. | volume = 12 | issue = 11 | pages = 987–93 |date=November 2005 | pmid = 16244663 | doi = 10.1038/nsmb1008 | url = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Li H, Byeon IJ, Ju Y, Tsai MD |title=Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. |journal=J. Mol. Biol. |volume=335 |issue= 1 |pages= 371–81 |year= 2004 |pmid= 14659764 |doi=10.1016/j.jmb.2003.10.032 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
- {{cite journal |vauthors=Byeon IJ, Li H, Song H, etal |title=Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 11 |pages= 987–93 |year= 2006 |pmid= 16244663 |doi= 10.1038/nsmb1008 }}
- {{cite journal |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
{{refend}}{{PDB Gallery|geneid=84365}}{{InterPro content|IPR021043}}{{gene-2-stub}} 1 : Protein domains |