| 词条 | Moco RNA motif |
| 释义 |
| Name = Moco (molybdenum cofactor) riboswitch | image = MOCO_RNA_motif_secondary_structure.jpg | width = | caption = Predicted secondary structure and sequence conservation of MOCO_RNA_motif | Symbol = MOCO_RNA_motif | AltSymbols = | Rfam = RF01055 | miRBase = | miRBase_family = | RNA_type = Cis-reg; riboswitch | Tax_domain = Bacteria | GO = | SO = {{SO|0005836}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The Moco RNA motif is a conserved RNA structure [1] that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor. Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor.[2] As these cofactors are not available in purified form, in vitro binding assays cannot be performed. However, the genetic data, complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches. References1. ^{{cite journal |vauthors=Weinberg Z, Barrick JE, Yao Z, etal |title=Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline |journal=Nucleic Acids Res. |volume=35 |issue=14 |pages=4809–19 |year=2007 |pmid=17621584 |doi=10.1093/nar/gkm487 |pmc=1950547}} 2. ^1 {{cite journal |vauthors=Regulski EE, Moy RH, Weinberg Z, etal |title=A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism |journal=Mol. Microbiol. |volume= 68|issue= 4|pages= 918–32|year=2008 |pmid=18363797 |doi=10.1111/j.1365-2958.2008.06208.x |pmc=2408646}} External links
2 : Cis-regulatory RNA elements|Riboswitch |
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