| 词条 | Liposarcoma | ||
| 释义 |
| name = Liposarcoma | synonyms = | image = Myxoid liposarcoma (06).JPG | caption = Micrograph of myxoid liposarcoma, H&E stain | pronounce = | field = Oncology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Liposarcoma is a cancer that arises in fat cells in soft tissue, such as that inside the thigh or in the retroperitoneum.[1] It is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope.[2] It is typically a large, bulky tumor, and tends to have multiple smaller satellites that extend beyond the main confines of the tumor. Liposarcomas, like all sarcomas, are rare.[3] Signs and symptomsPatients usually note a deep-seated mass in their soft tissue. Only when the tumor is very large do symptoms of pain or functional disturbances occur. Retroperitoneal tumors may present themselves with signs of weight loss and emaciation and abdominal pain. These tumors may also compress the kidney or ureter, leading to kidney failure. DiagnosisThe diagnosis is established by histologic examination of the tissue, i.e., biopsy or excision. Lipoblasts are often present; these are cells with an abundant clear multivacuolated cytoplasm and an eccentric darkly staining nucleus that is indented by the vacuoles. Medical imagingUltrasonography is may not be able to distinguish a liposarcoma from a benign lipoma, and therefore, MRI is the initial imaging of choice.[4] SubtypesSeveral subtypes of liposarcoma exist:
TreatmentTreatment of liposarcoma most often consists of surgical removal of the tumor and margin, occasionally radiation, and possibly chemotherapy, as well.[6] PrognosisThe prognosis varies depending on the site of origin, the type of cancer cell, tumor size, depth, and proximity to lymph nodes. Well-differentiated liposarcomas treated with surgery, intraoperative distilled water lavage[7] and radiation have a low recurrence rate (about 10%) and rarely metastasize.[8] Five-year survival rates vary from 56 to 100% based on histological subtype.[8] EpidemiologyMost frequent in middle-aged and older adults (age 40 and above), liposarcomas are the second-most common of all soft-tissue sarcomas, following malignant fibrous histiocytomas. Annually, 2.5 cases occur per million population. Society and cultureNotable cases
See also
References1. ^{{cite journal |author=Dei Tos AP |title=Liposarcoma: new entities and evolving concepts |journal=Ann Diagn Pathol |volume=4 |issue=4 |pages=252–66 |date=August 2000 |pmid=10982304 |doi=10.1053/adpa.2000.8133 |url=http://linkinghub.elsevier.com/retrieve/pii/S1092-9134(00)74153-0}} 2. ^{{Cite web|url = http://sarcomahelp.org/liposarcoma.html|title = What is Liposarcoma?|date = October 2012|accessdate = 2015-04-22|website = The Liddy Shriver Sarcoma Initiative|publisher = |last = Bell|first = Teresa}} 3. ^{{cite web|author=Goldstein-Rice, E|year=2008|title=The Importance of Treatment at a Specialty Center for Sarcomas|work=ESUN|url=http://sarcomahelp.org/sarcoma-centers.html}} 4. ^{{cite web|url=https://radiopaedia.org/articles/lipoma|title=Lipoma|author=Rohit Sharma |author2=Frank Gaillard |display-authors=etal|accessdate=2018-09-27|website=Radiopaedia}} 5. ^1 Content originally copied from: {{cite book|last1=Mak|first1=Chee-Wai|title=Sonography|last2=Tzeng|first2=Wen-Sheng|year=2012|doi=10.5772/27586|isbn=978-953-307-947-9}} from {{cite web|url=https://www.intechopen.com/books/sonography/sonography-of-the-scrotum|title=Sonography|author=Kerry Thoirs}} {{ISBN|978-953-307-947-9}}, Published: February 3, 2012, under the [https://creativecommons.org/licenses/by/3.0/ CC-BY-3.0 license]. 6. ^{{cite web |url=https://sarcoma.org.uk/sarcoma-types/liposarcoma-0#toc-6 |title= Liposarcoma|author= |date= |website=Sarcoma UK|publisher= |access-date= September 20, 2018}} 7. ^{{cite journal |vauthors=Song CH, Chai FY, Saukani MF, Singh H, Jiffre D |title=Management and Prevention of Recurrent Paratesticular Liposarcoma |journal=Malays J Med Sci. |volume=20 |issue=4 |pages=95–97 |date=July 2013 |pmc=3773360 |pmid=24044004}} 8. ^1 {{cite web|author1=Gebhardt, M |author2=Buecker, PJ|year=2004|title=Liposarcoma |work=ESUN|url=http://sarcomahelp.org/liposarcoma.html}} External links{{Medical resources| DiseasesDB = 31482 | ICD10 = | ICD9 = | ICDO = {{ICDO|8850|3}} | OMIM = | MedlinePlus = | eMedicineSubj = derm | eMedicineTopic = 856 | MeshID = D008080 }}{{Soft tissue tumors and sarcomas}} 3 : Dermal and subcutaneous growths|Sarcoma|Soft tissue disorders |
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