“MRNA guanylyltransferase”的意思、由来-开放百科全书

词条

MRNA guanylyltransferase

释义

Structural studies
References

{{enzyme
| Name = mRNA guanylyltransferase
| EC_number = 2.7.7.50
| CAS_number = 56941-23-2
| IUBMB_EC_number = 2/7/7/50
| GO_code = 0004484
| image =
| width =
| caption =
}}{{lowercase}}

In enzymology, a mRNA guanylyltransferase ({{EC number|2.7.7.50}}) is an enzyme that catalyzes the chemical reaction

GTP + (5')ppPur-mRNA diphosphate + G(5')pppPur-mRNA

Thus, the two substrates of this enzyme are GTP and (5')ppPur-mRNA, whereas its two products are diphosphate and G(5')pppPur-mRNA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:mRNA guanylyltransferase. Other names in common use include mRNA capping enzyme, messenger RNA guanylyltransferase, and Protein 2.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1CKM}}, {{PDB link|1CKN}}, {{PDB link|1CKO}}, {{PDB link|1P16}}, and {{PDB link|2C46}}.

References

{{cite journal | vauthors = Ensinger MJ, Martin SA, Paoletti E, Moss B | date = 1975 | title = Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 72 | pages = 2525–9 | pmid = 1058472 | doi = 10.1073/pnas.72.7.2525 | issue = 7 | pmc = 432801 }}
{{cite journal | vauthors = Groner Y, Gilboa E, Aviv H | date = 1978 | title = Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates | journal = Biochemistry | volume = 17 | pages = 977–82 | pmid = 629955 | doi = 10.1021/bi00599a005 | issue = 6 }}
{{cite journal | vauthors = Itoh N, Yamada H, Kaziro Y, Mizumoto K | date = 1987 | title = Messenger RNA guanylyltransferase from Saccharomyces cerevisiae Large scale purification, subunit functions, and subcellular localization | journal = J. Biol. Chem. | volume = 262 | pages = 1989–95 | pmid = 3029058 | issue = 5 }}
{{cite journal | vauthors = Martin SA, Moss B | date = 1975 | title = Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions | journal = J. Biol. Chem. | volume = 250 | pages = 9330–5 | pmid = 1194287 | issue = 24 }}
{{cite journal | vauthors = Martin SA, Paoletti E, Moss B | date = 1975 | title = Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions | journal = J. Biol. Chem. | volume = 250 | pages = 9322–9 | pmid = 1194286 | issue = 24 }}

2 : EC 2.7.7|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。