| 释义 |
- References
- Further reading
{{Infobox_gene}}39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.[2]
}}References1. ^{{cite journal |vauthors=Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T | title = The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders | journal = Genomics | volume = 77 | issue = 1–2 | pages = 65–70 |date=Sep 2001 | pmid = 11543634 | pmc = | doi = 10.1006/geno.2001.6622 }}
2. ^1 {{cite web | title = Entrez Gene: MRPL39 mitochondrial ribosomal protein L39| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54148| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=O'Brien TW, Fiesler SE, Denslow ND, etal |title=Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36043–51 |year= 2000 |pmid= 10593885 |doi=10.1074/jbc.274.51.36043 }}
- {{cite journal |vauthors=Spirina O, Bykhovskaya Y, Kajava AV, etal |title=Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing) |journal=Gene |volume=261 |issue= 2 |pages= 229–34 |year= 2001 |pmid= 11167009 |doi=10.1016/S0378-1119(00)00504-7 }}
- {{cite journal | author=O'Brien TW |title=Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease |journal=Gene |volume=286 |issue= 1 |pages= 73–9 |year= 2002 |pmid= 11943462 |doi=10.1016/S0378-1119(01)00808-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{refend}}{{GeneticTranslation}}{{Ribosome subunits}}{{gene-21-stub}}{{protein-stub}} 1 : Ribosomal proteins |