| 释义 |
- References
- Further reading
{{Infobox_gene}}28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.[3]
}}References1. ^{{cite journal |vauthors=Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL | title = The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present | journal = J Biol Chem | volume = 276 | issue = 22 | pages = 19363–74 |date=May 2001 | pmid = 11279123 | pmc = | doi = 10.1074/jbc.M100727200 }}
2. ^{{cite web | title = Entrez Gene: MRPS35 mitochondrial ribosomal protein S35| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60488| accessdate = }}
3. ^{{cite web | title = Entrez Gene: MRPS35 mitochondrial ribosomal protein S35| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60488| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ishiguchi H, Izumi H, Torigoe T, etal |title=ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. |journal=Int. J. Cancer |volume=111 |issue= 6 |pages= 900–9 |year= 2004 |pmid= 15300802 |doi= 10.1002/ijc.20358 }}
- {{cite journal |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1–2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
- {{cite journal |vauthors=Koc EC, Burkhart W, Blackburn K, etal |title=Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach |journal=Protein Sci. |volume=10 |issue= 3 |pages= 471–81 |year= 2001 |pmid= 11344316 |doi=10.1110/ps.35301 | pmc=2374141 }}
{{refend}}{{GeneticTranslation}}{{Ribosome subunits}}{{gene-12-stub}}{{protein-stub}} 1 : Ribosomal proteins |