| 释义 |
- Function
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.[1][2] Function This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.[2] Interactions MRVI1 has been shown to interact with ITPR1[3] and PRKG1.[3][4] References 1. ^{{cite journal | vauthors = Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P, Jenkins NA, Copeland NG | title = Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1 | journal = Oncogene | volume = 18 | issue = 12 | pages = 2069–84 | date = June 1999 | pmid = 10321731 | pmc = | doi = 10.1038/sj.onc.1202419 }}
2. ^1 {{cite web | title = Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10335| accessdate = }}
3. ^1 {{cite journal | vauthors = Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P | title = Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta | journal = Nature | volume = 404 | issue = 6774 | pages = 197–201 | date = March 2000 | pmid = 10724174 | doi = 10.1038/35004606 }}
4. ^{{cite journal | vauthors = Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J | title = Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24153–9 | date = June 2001 | pmid = 11309393 | doi = 10.1074/jbc.M101530200 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC | title = Sequence identification of 2,375 human brain genes | journal = Nature | volume = 355 | issue = 6361 | pages = 632–4 | year = 1992 | pmid = 1538749 | doi = 10.1038/355632a0 }}
- {{cite journal | vauthors = Baltensperger K, Chiesi M, Carafoli E | title = Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process | journal = Biochemistry | volume = 29 | issue = 41 | pages = 9753–60 | year = 1990 | pmid = 2271613 | doi = 10.1021/bi00493a035 }}
- {{cite journal | vauthors = Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P | title = Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta | journal = Nature | volume = 404 | issue = 6774 | pages = 197–201 | year = 2000 | pmid = 10724174 | doi = 10.1038/35004606 }}
- {{cite journal | vauthors = Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J | title = Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24153–9 | year = 2001 | pmid = 11309393 | doi = 10.1074/jbc.M101530200 }}
- {{cite journal | vauthors = Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, Hofmann F | title = Association of phospholamban with a cGMP kinase signaling complex | journal = Biochem. Biophys. Res. Commun. | volume = 300 | issue = 1 | pages = 155–60 | year = 2003 | pmid = 12480535 | doi = 10.1016/S0006-291X(02)02799-7 }}
- {{cite journal | vauthors = Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A, Hofmann F, Allescher HD | title = InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12551–9 | year = 2004 | pmid = 14729908 | doi = 10.1074/jbc.M313365200 }}
- {{cite journal | vauthors = Casteel DE, Boss GR, Pilz RB | title = Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif | journal = J. Biol. Chem. | volume = 280 | issue = 46 | pages = 38211–8 | year = 2005 | pmid = 16166082 | doi = 10.1074/jbc.M507021200 }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
- {{cite journal | vauthors = Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J | title = IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation | journal = Blood | volume = 109 | issue = 2 | pages = 552–9 | year = 2007 | pmid = 16990611 | doi = 10.1182/blood-2005-10-026294 }}
{{refend}} External links - {{UCSC genome browser|MRVI1}}
- {{UCSC gene details|MRVI1}}
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