“MSI1”的意思、由来-开放百科全书

This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation.^[2]^[3]

Clinical significance

Over expression of this gene is associated with the grade of the malignancy and proliferative activity in gliomas and melanomas.^[2]

MSI1 is highly expressed in neural progenitor cells and is required for normal development of the brain. A mutation in these gene is responsible for autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome and may explain why these cells are highly susceptible to Zika virus infection.^[4]^[5]

See also

References

1. ^{{cite journal | vauthors = Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, Ikeuchi T, Tsuji S, Satoh H, Okano H | title = The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells | journal = Genomics | volume = 52 | issue = 3 | pages = 382–4 | date = September 1998 | pmid = 9790759 | pmc = | doi = 10.1006/geno.1998.5456 }}
2. ^¹{{cite journal | vauthors = Glazer RI, Vo DT, Penalva LO | title = Musashi1: an RBP with versatile functions in normal and cancer stem cells | journal = Frontiers in Bioscience | volume = 17 | issue = | pages = 54–64 | year = 2012 | pmid = 22201732 | doi = 10.2741/3915 }}
3. ^¹{{cite web | title = Entrez Gene: MSI1 musashi homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4440| accessdate = }}
4. ^{{cite journal | vauthors = Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F | title = Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication | journal = Science | volume = 357 | issue = 6346 | pages = 83–88 | year = 2017 | pmid = 28572454 | doi = 10.1126/science.aam9243 }}
5. ^{{cite journal | vauthors = Griffin DE | title = Why are neurons susceptible to Zika virus? | journal = Science | volume = 357 | issue = 6346 | pages = 33–34 | year = 2017 | pmid = 28684491 | doi = 10.1126/science.aan8626 }}

Further reading

{{cite journal | vauthors = Okano H, Imai T, Okabe M | title = Musashi: a translational regulator of cell fate | journal = Journal of Cell Science | volume = 115 | issue = Pt 7 | pages = 1355–9 | date = April 2002 | pmid = 11896183 | doi = }}

{{cite journal | vauthors = Toda M, Iizuka Y, Yu W, Imai T, Ikeda E, Yoshida K, Kawase T, Kawakami Y, Okano H, Uyemura K | title = Expression of the neural RNA-binding protein Musashi1 in human gliomas | journal = Glia | volume = 34 | issue = 1 | pages = 1–7 | date = April 2001 | pmid = 11284014 | doi = 10.1002/glia.1034 }}

{{cite journal | vauthors = Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H | title = The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA | journal = Molecular and Cellular Biology | volume = 21 | issue = 12 | pages = 3888–900 | date = June 2001 | pmid = 11359897 | pmc = 87052 | doi = 10.1128/MCB.21.12.3888-3900.2001 }}

{{cite journal | vauthors = Sakakibara S, Nakamura Y, Satoh H, Okano H | title = Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS | journal = The Journal of Neuroscience | volume = 21 | issue = 20 | pages = 8091–107 | date = October 2001 | pmid = 11588182 | doi = }}

{{cite journal | vauthors = Kanemura Y, Mori K, Sakakibara S, Fujikawa H, Hayashi H, Nakano A, Matsumoto T, Tamura K, Imai T, Ohnishi T, Fushiki S, Nakamura Y, Yamasaki M, Okano H, Arita N | title = Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity | journal = Differentiation; Research in Biological Diversity | volume = 68 | issue = 2-3 | pages = 141–52 | date = September 2001 | pmid = 11686236 | doi = 10.1046/j.1432-0436.2001.680208.x }}

{{cite journal | vauthors = Kanemura Y, Sakakibara S, Okano H | title = Identification of Musashi1-positive cells in human normal and neoplastic neuroepithelial tissues by immunohistochemical methods | journal = Methods in Molecular Biology | volume = 198 | issue = | pages = 273–81 | year = 2002 | pmid = 11951628 | doi = 10.1385/1-59259-186-8:273 | isbn = 1-59259-186-8 }}

{{cite journal | vauthors = Shu HJ, Saito T, Watanabe H, Ito JI, Takeda H, Okano H, Kawata S | title = Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 150–4 | date = April 2002 | pmid = 12054577 | doi = 10.1016/S0006-291X(02)00175-4 }}

{{cite journal | vauthors = Miyanoiri Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, Okano H, Katahira M | title = Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics | journal = The Journal of Biological Chemistry | volume = 278 | issue = 42 | pages = 41309–15 | date = October 2003 | pmid = 12907678 | doi = 10.1074/jbc.M306210200 }}

{{cite journal | vauthors = Nishimura S, Wakabayashi N, Toyoda K, Kashima K, Mitsufuji S | title = Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium | journal = Digestive Diseases and Sciences | volume = 48 | issue = 8 | pages = 1523–9 | date = August 2003 | pmid = 12924647 | doi = 10.1023/A:1024763723240 }}

{{cite journal | vauthors = Lovell MA, Markesbery WR | title = Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease | journal = Journal of Neuropathology and Experimental Neurology | volume = 64 | issue = 8 | pages = 675–80 | date = August 2005 | pmid = 16106215 | doi = 10.1097/01.jnen.0000173891.17176.5b }}

{{cite journal | vauthors = Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM | title = The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1 | journal = Molecular and Cellular Neurosciences | volume = 31 | issue = 1 | pages = 85–96 | date = January 2006 | pmid = 16214366 | doi = 10.1016/j.mcn.2005.09.003 }}

{{cite journal | vauthors = Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG | title = Musashi1 antigen expression in human fetal germinal matrix development | journal = Experimental Neurology | volume = 201 | issue = 2 | pages = 515–8 | date = October 2006 | pmid = 16777095 | doi = 10.1016/j.expneurol.2006.04.023 }}

Function

Clinical significance

See also

References

Further reading