| 词条 | Murine gammaherpesvirus 68 |
| 释义 |
| virus_group = i | ordo = Herpesvirales | familia = Herpesviridae | subfamilia = Gammaherpesvirinae | genus = Rhadinovirus | species = Murid herpesvirus 4 | subspecies = Murid herpesvirus 68 (MHV-68) }} Murine gammaherpesvirus 68 (MHV-68) aka murid herpesvirus 68 is an isolate of Murid herpesvirus 4 which is a virus in the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family of Herpesviridae. MHV-68 serves as a model for study of human gammaherpesviruses which cause significant human disease including B-cell lymphoma and Kaposi's sarcoma. The WUMS strain of MHV-68 was fully sequenced and annotated in 1997,[1] and the necessity of most of its genes in viral replication was characterized by random transposon mutagenesis study .[2] MHV-68 surface proteinsAlpha-, beta-, and gammaherpesviruses display a heterodimer composed of glycoprotein H (gH) and glycoprotein L (gL) on their envelopes. This receptor is involved in the cell-to-cell transmission of the virus. Glycoprotein H has two conformations. Glycoprotein L is a chaperone protein which assures that gH takes on the correct conformation. When herpesviruses lack gL, gH misfolds. When alpha- or betaherpesviruses lack gL, they are noninfectious. When Murine Gammaherpesvirus 68 lacks gL, it remains infectious but is less able to bind to fibroblasts and epithelial cells.[3]The open reading frame M7 of the MHV-68 genome encodes for the surface receptor glycoprotein 150 (gp150). It is homologous to the Epstein-Barr virus membrane antigen gp350/220.[4] MHV-68 is more closely related to the Kaposi's Sarcoma-associated herpesvirus (KSHV) than it is to the Epstein-Barr virus. Glycoprotein K8.1 is the KSHV homolog of MHV-68 gp150.[4] MHV-68 is a very close relative of MHV-72. The MHV-68 M7 gene differs from the corresponding MHV-72 gene by five point mutations which alter four codons.[5] Glycoprotein 150 allows MHV-68 to bind to B-cells.[4] References1. ^{{cite journal |journal = Journal of Virology |date= August 1997 |pages= 5894–904 | volume= 71 |issue= 8 |title = Complete sequence and genomic analysis of murine gammaherpesvirus 68 |author1=Herbet W. Virgin IV |author2=Philip Latreille |author3=Pamela Wamsley |author4=Kymberlie Hallsworth |author5=Karen E. Weck |author6=Albert J. Dal Canto |author7=Samuel H. Speck |last-author-amp=yes |url=http://jvi.asm.org/cgi/reprint/71/8/5894?view=long&pmid=9223479 |pmid=9223479 |pmc=191845}} {{DEFAULTSORT:Murid Herpesvirus 68}}2. ^{{cite journal |journal = Proceedings of the National Academy of Sciences of the United States of America |date=March 2005 |pages= 3805–10 | volume= 102 |issue= 10 | doi = 10.1073/pnas.0404521102 |title = Identification of viral genes essential for replication of murine γ-herpesvirus 68 using signature-tagged mutagenesis |author1=Moon Jung Song |author2=Seungmin Hwang |author3=Wendy H. Wong |author4=Ting-Ting Wu |author5=Sangmi Lee |author6=Hsiang-I Liao |author7=Ren Sun |last-author-amp=yes |url=http://www.pnas.org/content/102/10/3805.abstract?ck=nck |pmid=15738413 |pmc=553290}} 3. ^{{cite journal |journal = Journal of Virology |date = January 2007 |pages= 280–291 | volume=81 |issue= 1 |title = Glycoprotein L Disruption Reveals Two Functional Forms of the Murine Gammaherpesvirus 68 Glycoprotein H |author1=Laurent Gillet |author2=Janet S. May |author3=Susanna Colaco |author4=Philip G. Stevenson |last-author-amp=yes |url=http://jvi.asm.org/cgi/content/abstract/81/1/280 |doi=10.1128/jvi.01616-06 |pmid=17050601 |pmc=1797276}} 4. ^1 {{cite journal |journal = Journal of Virology |date= October 2004 | pages= 10449–10459 |volume= 78 |issue= 19 |title = In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis |author1=James P. Stewart |author2=Ondine J. Silvia |author3=Isobel M. D. Atkin |author4=David J. Hughes |author5=Bahram Ebrahimi |author6=Heiko Adler |last-author-amp=yes |url=http://jvi.asm.org/cgi/content/full/78/19/10449 |doi=10.1128/jvi.78.19.10449-10459.2004 |pmid=15367611 |pmc=516434}} 5. ^1 {{ cite journal |journal = Virus Genes |date=Jan 2003 |volume=26|title = Murine gammaherpesvirus (MHV) M7 gene encoding glycoprotein 150 (gp150): difference in the sequence between 72 and 68 strains |vauthors=Macáková K, Matis J, Rezuchová I, Kúdela O, Raslová H, Kúdelová M |pmid = 12683351 |issue = 1 |pages = 89–95 |doi = 10.1023/a:1022390407991}} 2 : Gammaherpesvirinae|Animal virology |
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