| City | Country | IATA | ICAO | Airport | Refs |
|---|
| Asunción | Paraguay | ASU | SGAS | Silvio Pettirossi International Airport |
| Belo Horizonte | Brazil | CNF | SBCF | Tancredo Neves International Airport |
| Belize City | Belize | BZE | MZBZ | Philip S. W. Goldson International Airport | [2] |
| Barranquilla | Colombia | BAQ | SKBQ | Ernesto Cortissoz International Airport |
| Bogota | Colombia | BOG | SKBO | El Dorado International Airport |
| Boston | United States | BOS | KBOS | Logan International Airport | [3] |
| Brasilia | Brazil | BSB | SBBR | Brasília International Airport |
| Bridgetown | Barbados | BGI | TBPB | Grantley Adams International Airport | [4][5] |
| Bucaramanga | Colombia | BGA | SKBG | Palonegro International Airport |
| Buenos Aires | Argentina | EZE | SAEZ | Ministro Pistarini International Airport |
| Cali | Colombia | CLO | SKCL | Alfonso Bonilla Aragón International Airport |
| Cartagena | Colombia | CTG | SKCG | Rafael Núñez International Airport |
| Campinas | Brazil | VCP | SBKP | Viracopos International Airport | [6] |
| Cancún | Mexico | CUN | MMUN | Cancún International Airport |
| Caracas | Venezuela | CCS | SVMI | Simon Bolivar International Airport |
| Chicago | United States | ORD | KORD | O'Hare International Airport |
| Chiclayo | Peru | CIX | SPHI | FAP Captain José Abelardo Quiñones Gonzáles International Airport | [7] |
| Córdoba | Argentina | COR | SACO | Ingeniero Aeronáutico Ambrosio L.V. Taravella International Airport |
| David | Panama | DAV | MPDA | Enrique Malek International Airport | [8] |
| Denver | United States | DEN | KDEN | Denver International Airport | [9] |
| Fort Lauderdale | United States | FLL | KFLL | Fort Lauderdale-Hollywood International Airport | [10] |
| Fortaleza | Brazil | FOR | SBFZ | Pinto Martins – Fortaleza International Airport | [4] |
| Georgetown | Guyana | GEO | SYCJ | Cheddi Jagan International Airport | [11] |
| Guadalajara | Mexico | GDL | MMGL | Miguel Hidalgo y Costilla International Airport |
| Guatemala City | Guatemala | GUA | MGGT | La Aurora International Airport |
| Guayaquil | Ecuador | GYE | SEGU | José Joaquín de Olmedo International Airport |
| Havana | Cuba | HAV | MUHA | José Martí International Airport |
| Holguín | Cuba | HOG | MUHG | Frank País Airport |
| Iquitos | Peru | IQT | SPQT | Crnl. FAP Francisco Secada Vignetta International Airport |
| Kingston | Jamaica | KIN | MKJP | Norman Manley International Airport |
| Las Vegas | United States | LAS | KLAS | McCarran International Airport |
| Liberia | Costa Rica | LIR | MRLB | Daniel Oduber Quirós International Airport |
| Lima | Peru | LIM | SPIM | Jorge Chávez International Airport |
| Los Angeles | United States | LAX | KLAX | Los Angeles International Airport |
| Managua | Nicaragua | MGA | MNMG | Augusto C. Sandino International Airport |
| Manaus | Brazil | MAO | SBEG | Eduardo Gomes International Airport |
| Maracaibo | Venezuela | MAR | SVMC | La Chinita International Airport |
| Medellín | Colombia | MDE | SKRG | José María Córdova International Airport |
| Mendoza | Argentina | MDZ | SAME | Governor Francisco Gabrielli International Airport | [12] |
| Mexico City | Mexico | MEX | MMMX | Mexico City International Airport |
| Miami | United States | MIA | KMIA | Miami International Airport |
| Montego Bay | Jamaica | MBJ | MKJS | Sangster International Airport |
| Monterrey | Mexico | MTY | MMMY | General Mariano Escobedo International Airport |
| Montevideo | Uruguay | MVD | SUMU | Cesareo Berisso Airport |
| Montreal | Canada | YUL | CYUL | Montréal-Pierre Elliott Trudeau International Airport | |
| Nassau | Bahamas | NAS | MYNN | Lynden Pindling International Airport |
| New Orleans | United States | MSY | KMSY | Louis Armstrong International Airport | [13] |
| New York City | United States | JFK | KJFK | John F. Kennedy International Airport |
| Oranjestad | Aruba | AUA | TNCA | Queen Beatrix International Airport |
| Orlando | United States | MCO | KMCO | Orlando International Airport |
| Panama City | Panama | PTY | MPTO | Tocumen International Airport |
Paramaribo
Begins July 6, 2019 | Suriname | PBM | SMJP | Johan Adolf Pengel International Airport | [14] |
| Pereira | Colombia | PEI | SKPE | Matecaña International Airport |
| Philipsburg | Sint Maarten | SXM | TNCM | Princess Juliana International Airport |
| Port of Spain | Trinidad and Tobago | POS | TTPP | Piarco International Airport |
| Port-au-Prince | Haiti | PAP | MTPP | Toussaint Louverture International Airport |
| Porto Alegre | Brazil | POA | SBPA | Salgado Filho International Airport |
| Puebla | Mexico | PBC | MMPB | Puebla International Airport | [15] |
| Puerto Vallarta | Mexico | PVR | MMPR | Licenciado Gustavo Díaz Ordaz International Airport | [16] |
| Punta Cana | Dominican Republic | PUJ | MDPC | Punta Cana International Airport |
| Quito | Ecuador | UIO | SEQM | Mariscal Sucre International Airport |
| Recife | Brazil | REC | SBRF | Recife Airport |
| Rio de Janeiro | Brazil | GIG | SBGL | Rio de Janeiro-Galeão International Airport |
| Rosario | Argentina | ROS | SAAR | Islas Malvinas International Airport | [17] |
| Salta | Argentina | SLA | SASA | Martín Miguel de Güemes International Airport | [18] |
| Salvador da Bahia | Brazil | SSA | SBSV | Deputado Luís Eduardo Magalhães International Airport | [4] |
| San Andres Island | Colombia | ADZ | SKSP | Gustavo Rojas Pinilla International Airport |
| San Francisco | United States | SFO | KSFO | San Francisco International Airport | [19] |
| San José | Costa Rica | SJO | MROC | Juan Santamaría International Airport |
| San Juan | Puerto Rico | SJU | TJSJ | Luis Muñoz Marín International Airport |
| San Pedro Sula | Honduras | SAP | MHLM | Ramón Villeda Morales International Airport |
| San Salvador | El Salvador | SAL | MSLP | Monseñor Óscar Arnulfo Romero International Airport |
| Santa Clara | Cuba | SNU | MUSC | Abel Santamaria International Airport |
| Santa Cruz de la Sierra | Bolivia | VVI | SLVR | Viru Viru International Airport |
| Santiago | Chile | SCL | SCEL | Comodoro Arturo Merino Benítez International Airport |
| Santiago de los Caballeros | Dominican Republic | STI | MDST | Cibao International Airport |
| Santo Domingo | Dominican Republic | SDQ | MDSD | Las Américas International Airport |
| São Paulo | Brazil | GRU | SBGR | São Paulo-Guarulhos International Airport |
| Tampa | United States | TPA | KTPA | Tampa International Airport | [20] |
| Tegucigalpa | Honduras | TGU | MHTG | Toncontín International Airport |
| Toronto | Canada | YYZ | CYYZ | Toronto Pearson International Airport |
| Valencia | Venezuela | VLN | SVVA | Arturo Michelena International Airport |
| Villahermosa | Mexico | VSA | MMVA | Carlos Rovirosa Pérez International Airport | [15] |
| Washington, D.C. | United States | IAD | KIAD | Washington Dulles International Airport |
| Willemstad | Curaçao | CUR | TNCC | Hato International Airport |
1. ^{{Cite web|url=https://destinationsguide.copaair.com/en-pa/|publisher=Copa Airlines|title=Copa Airlines' Flights and Destinations}}
2. ^{{cite web|url=http://airlineroute.net/2015/07/30/cm-bze-dec15/|title=Copa Airlines Adds Belize Service from Dec 2015|publisher=|access-date=30 July 2015}}
3. ^{{cite web|url=http://www.boston.com/businessupdates/2013/01/23/copa-airlines-schedules-nonstop-boston-panama-service-for-july/UMO38aum9GvwMZD9E8aiNI/story.html|title=Copa Airlines to start nonstop Boston-Panama service in July|date=23 January 2013|website=Boston.com|access-date=30 January 2018}}
4. ^1 2 {{cite web|url=http://www.copaair.com/en/web/gs/copa-airlines-expands-its-fleet-and-adds-destinations-in-2018?d1=SMO_JAN_MM_es_29012018-TWOP|title=Copa Airlines expands its fleet and adds destinations in 2018 - Copa Airlines|website=www.CopaAir.com|access-date=30 January 2018}}
5. ^{{cite web|url=https://www.routesonline.com/news/38/airlineroute/277199/copa-airlines-plans-barbados-launch-in-july-2018/|title=Copa Airlines plans Barbados launch in July 2018|first=UBM (UK) Ltd.|last=2018|publisher=|accessdate=5 July 2018}}
6. ^{{cite web|url=http://airlineroute.net/2015/11/17/cm-vcp-dec15cxld/|title=Copa Airlines Cancels Sao Paulo Viracopos/Campinas from Dec 2015|publisher=Airlineroute.net|date=17 November 2015|access-date=17 November 2015}}
7. ^{{cite web|title=Copa Airlines Adds Chiclayo Service from late-June 2016|url=http://airlineroute.net/2016/03/21/cm-ptycix-jun16/|website=airlineroute.net|publisher=airlineroute.net|access-date=21 March 2016}}
8. ^{{cite web|url=http://airlineroute.net/2014/12/04/cm-dav-jan15/|title=Copa Airlines Adds Domestic Service from Jan 2015|first=UBM (UK) Ltd.|last=2018|website=AirlineRoute.net|access-date=30 January 2018}}
9. ^{{cite web|url=http://www.denverpost.com/2017/04/19/copa-airlines-denver-international-airport/|title=Copa Airlines added to international lineup at Denver International Airport|date=19 April 2017|website=DenverPost.com|access-date=30 January 2018}}
10. ^{{cite web|url=http://www.sun-sentinel.com/business/consumer-talk-blog/sfl-copa-lauderdale-panama-service-20140122,0,2049534.story|title=Copa Airlines: New Lauderdale-Panama service starts July 11|publisher=Sun Senitel|date=22 January 2014|access-date=22 January 2014}}
11. ^{{cite web |url=http://www.canalpluspr.com/news/index.php?option=com_content&task=view&id=1204&Itemid=52 |title=Archived copy |accessdate=22 January 2014 |deadurl=yes |archiveurl=https://web.archive.org/web/20140201203439/http://www.canalpluspr.com/news/index.php?option=com_content&task=view&id=1204&Itemid=52 |archivedate=1 February 2014 }}
12. ^{{cite web|url=http://laestrella.com.pa/economia/panama-abre-nueva-ruta-argentina/24009814|title=Panamá abre nueva ruta a Argentina|date=28 June 2017|website=LaEstrella.com.pa|access-date=30 January 2018}}
13. ^{{cite web|url=http://airlineroute.net/2015/02/04/cm-msy-jun15/|title=Copa Airlines to Start New Orleans Service from late-June 2015|first=UBM (UK) Ltd.|last=2018|website=AirlineRoute.net|access-date=30 January 2018}}
14. ^https://www.routesonline.com/news/38/airlineroute/282512/copa-airlines-adds-paramaribo-service-from-july-2019/
15. ^1 {{cite web|url=http://enelaire.mx/copa-airlines-anuncia-dos-nuevos-destinos-a-mexico-y-uno-a-estados-unidos/|title=COPA Airlines Anuncia Dos Nuevos Destinos a México y Uno a Estados Unidos|website=Enelaire.mx|access-date=30 January 2018}}
16. ^{{cite web|url=http://enelaire.mx/copa-airlines-anuncia-vuelos-a-puerto-vallarta/|title=Copa Airlines announces flights to Puerto Vallarta|language=Spanish|publisher=EnElAire|date=May 2018|accessdate=31 May 2018}}
17. ^{{cite web|title=Copa Airlines Adds Rosario Service from late-July 2016|url=http://airlineroute.net/2016/03/21/cm-ptycix-jun16/|website=airlineroute.net|publisher=airlineroute.net|access-date=21 March 2016}}
18. ^{{cite web|url=https://www.routesonline.com/news/38/airlineroute/279460/copa-airlines-launches-salta-service-from-dec-2018/|title=Copa Airlines launches Salta service from Dec 2018}}
19. ^{{cite web|url=http://www.flysfo.com/media/press-releases/sfo-welcomes-copa-airlines|title=SFO welcomes Copa Airlines|publisher=FlySFO.com|date=29 May 2015|access-date=29 May 2015}}
20. ^https://finance.yahoo.com/news/copa-airlines-announces-nonstop-between-203400966.html;_ylt=A2KJ2PZoPudRUhEAK3PQtDMD
{{DEFAULTSORT:Copa Airlines Destinations}}