| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene.[1][2] This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail. Function Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, but rarely in non-muscle cells. These isoforms show expression that is spatially and temporally regulated during development.[2] References 1. ^{{cite journal | vauthors = Leinwand LA, Saez L, McNally E, Nadal-Ginard B | title = Isolation and characterization of human myosin heavy chain genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 80 | issue = 12 | pages = 3716–20 | date = June 1983 | pmid = 6304733 | pmc = 394121 | doi = 10.1073/pnas.80.12.3716 }}
2. ^1 {{cite web | title = Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4619| accessdate = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L | title = Organization of the human skeletal myosin heavy chain gene cluster | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 24 | pages = 12078–82 | date = December 1992 | pmid = 1465443 | pmc = 50701 | doi = 10.1073/pnas.89.24.12078 }}
- {{cite journal | vauthors = Saez L, Leinwand LA | title = Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle | journal = Nucleic Acids Research | volume = 14 | issue = 7 | pages = 2951–69 | date = April 1986 | pmid = 2421254 | pmc = 339714 | doi = 10.1093/nar/14.7.2951 }}
- {{cite journal | vauthors = Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S | title = Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle | journal = The American Journal of Physiology | volume = 267 | issue = 6 Pt 1 | pages = C1723–8 | date = December 1994 | pmid = 7545970 | doi = 10.1152/ajpcell.1994.267.6.C1723}}
- {{cite journal | vauthors = Weiss A, McDonough D, Wertman B, Acakpo-Satchivi L, Montgomery K, Kucherlapati R, Leinwand L, Krauter K | title = Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 6 | pages = 2958–63 | date = March 1999 | pmid = 10077619 | pmc = 15877 | doi = 10.1073/pnas.96.6.2958 }}
- {{cite journal | vauthors = Weiss A, Schiaffino S, Leinwand LA | title = Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity | journal = Journal of Molecular Biology | volume = 290 | issue = 1 | pages = 61–75 | date = July 1999 | pmid = 10388558 | doi = 10.1006/jmbi.1999.2865 }}
- {{cite journal | vauthors = Daugaard JR, Nielsen JN, Kristiansen S, Andersen JL, Hargreaves M, Richter EA | title = Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training | journal = Diabetes | volume = 49 | issue = 7 | pages = 1092–5 | date = July 2000 | pmid = 10909963 | doi = 10.2337/diabetes.49.7.1092 }}
- {{cite journal | vauthors = Korfage JA, Brugman P, Van Eijden TM | title = Intermuscular and intramuscular differences in myosin heavy chain composition of the human masticatory muscles | journal = Journal of the Neurological Sciences | volume = 178 | issue = 2 | pages = 95–106 | date = September 2000 | pmid = 11018701 | doi = 10.1016/S0022-510X(00)00372-5 }}
- {{cite journal | vauthors = Konig S, Burkman J, Fitzgerald J, Mitchell M, Su L, Stedman H | title = Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27593–605 | date = August 2002 | pmid = 11971910 | doi = 10.1074/jbc.M203162200 }}
- {{cite journal | vauthors = Villacé P, Marión RM, Ortín J | title = The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs | journal = Nucleic Acids Research | volume = 32 | issue = 8 | pages = 2411–20 | year = 2004 | pmid = 15121898 | pmc = 419443 | doi = 10.1093/nar/gkh552 }}
- {{cite journal | vauthors = Pontén EM, Stål PS | title = Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis | journal = Journal of the Neurological Sciences | volume = 253 | issue = 1–2 | pages = 25–33 | date = February 2007 | pmid = 17196619 | doi = 10.1016/j.jns.2006.11.006 }}
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