| 释义 |
- References
- Further reading
{{Infobox_gene}}Myocardin is a protein that in humans is encoded by the MYOCD gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM][3]
}}References1. ^{{cite journal |vauthors=Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN | title = Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor | journal = Cell | volume = 105 | issue = 7 | pages = 851–62 |date=Jul 2001 | pmid = 11439182 | pmc = | doi =10.1016/S0092-8674(01)00404-4 }}
2. ^{{cite journal |vauthors=Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN | title = Potentiation of serum response factor activity by a family of myocardin-related transcription factors | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 23 | pages = 14855–60 |date=Nov 2002 | pmid = 12397177 | pmc = 137508 | doi = 10.1073/pnas.222561499 }}
3. ^1 {{cite web | title = Entrez Gene: MYOCD myocardin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93649| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Du KL, Ip HS, Li J, etal |title=Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. |journal=Mol. Cell. Biol. |volume=23 |issue= 7 |pages= 2425–37 |year= 2003 |pmid= 12640126 |doi=10.1128/MCB.23.7.2425-2437.2003 | pmc=150745 }}
- {{cite journal |vauthors=Wang Z, Wang DZ, Pipes GC, Olson EN |title=Myocardin is a master regulator of smooth muscle gene expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 12 |pages= 7129–34 |year= 2003 |pmid= 12756293 |doi= 10.1073/pnas.1232341100 | pmc=165841 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Du KL, Chen M, Li J, etal |title=Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17578–86 |year= 2004 |pmid= 14970199 |doi= 10.1074/jbc.M400961200 }}
- {{cite journal |vauthors=Wang Z, Wang DZ, Hockemeyer D, etal |title=Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. |journal=Nature |volume=428 |issue= 6979 |pages= 185–9 |year= 2004 |pmid= 15014501 |doi= 10.1038/nature02382 }}
- {{cite journal |vauthors=van Tuyn J, Knaän-Shanzer S, van de Watering MJ, etal |title=Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin. |journal=Cardiovasc. Res. |volume=67 |issue= 2 |pages= 245–55 |year= 2006 |pmid= 15907818 |doi= 10.1016/j.cardiores.2005.04.013 }}
- {{cite journal |vauthors=Liu ZP, Wang Z, Yanagisawa H, Olson EN |title=Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. |journal=Dev. Cell |volume=9 |issue= 2 |pages= 261–70 |year= 2005 |pmid= 16054032 |doi= 10.1016/j.devcel.2005.05.017 }}
- {{cite journal |vauthors=Doi H, Iso T, Yamazaki M, etal |title=HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 11 |pages= 2328–34 |year= 2006 |pmid= 16151017 |doi= 10.1161/01.ATV.0000185829.47163.32 }}
- {{cite journal |vauthors=Zody MC, Garber M, Adams DJ, etal |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |journal=Nature |volume=440 |issue= 7087 |pages= 1045–9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 | pmc=2610434 }}
- {{cite journal |vauthors=Chow N, Bell RD, Deane R, etal |title=Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 3 |pages= 823–8 |year= 2007 |pmid= 17215356 |doi= 10.1073/pnas.0608251104 | pmc=1783398 }}
- {{cite journal |vauthors=Milyavsky M, Shats I, Cholostoy A, etal |title=Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. |journal=Cancer Cell |volume=11 |issue= 2 |pages= 133–46 |year= 2007 |pmid= 17292825 |doi= 10.1016/j.ccr.2006.11.022 }}
- {{cite journal |vauthors=Li HJ, Haque Z, Lu Q, etal |title=Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4065–70 |year= 2007 |pmid= 17360478 |doi= 10.1073/pnas.0611639104 | pmc=1820709 }}
- {{cite journal |vauthors=Pijnappels DA, van Tuyn J, de Vries AA, etal |title=Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts. |journal=Circulation |volume=116 |issue= 18 |pages= 2018–28 |year= 2007 |pmid= 17938287 |doi= 10.1161/CIRCULATIONAHA.107.712935 }}
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