Mystery Mansion may refer to:

• Mystery Mansion (video game), a late 1970s text-based adventure video game
• Mystery Mansion (1983 film), a 1983 family movie
• Mystery Mansion, a haunted house/darkride attraction operated at Indiana Beach Amusement Park, Monticello IN. from 1969 to 1998
• Mystery Mansion, a 2007 Nintendo DS video game by 505 Games
• Mystery Mansion (board game), a board game first offered by Milton Bradley in 1984, then updated and released by Parker Brothers as an electronic version in the 1990s
• Mystery Mansion, a 2009 PC video game by Innesoft

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