| 词条 | N6-Cyclopentyladenosine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | Name = N6-Cyclopentyladenosine | verifiedrevid = 425038207 | ImageFile=N6-Cyclopentyladenosine.svg | ImageSize=200px | IUPACName=(2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | OtherNames= |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=41552-82-3 | PubChem=657378 | SMILES= C1CCC(C1)NC2=NC=NC3=C2N=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 571479 | InChI = 1/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1 | InChIKey = SQMWSBKSHWARHU-SDBHATREBV | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = SQMWSBKSHWARHU-SDBHATRESA-N |Section2={{Chembox Properties | C=15 | H=21 | N=5 | O=4 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}N6-Cyclopentyladenosine (CPA) is a drug which acts as a selective adenosine A1 receptor agonist.[1] It has mainly cardiovascular effects with only subtle alterations of behavior.[2] CPA is widely used in scientific research into the adenosine receptors and has been used to derive a large family of derivatives.[3][4][5][6][7] See also
References1. ^{{cite journal |vauthors=Williams M, Braunwalder A, Erickson TJ |title=Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue |journal=Naunyn-Schmiedeberg's Archives of Pharmacology |volume=332 |issue=2 |pages=179–183 |date=February 1986 |pmid=3703020 |doi= 10.1007/BF00511410|url=}} {{Adenosinergics}}{{DEFAULTSORT:Cyclopentyladenosine, N6-}}{{cardiovascular-drug-stub}}2. ^{{cite journal |vauthors=Coffin VL, Spealman RD |title=Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=241 |issue=1 |pages=76–83 |date=April 1987 |pmid=3572798 |doi= |url=}} 3. ^{{cite journal |vauthors=Zablocki JA, Wu L, Shryock J, Belardinelli L |title=Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF) |journal=Current Topics in Medicinal Chemistry |volume=4 |issue=8 |pages=839–854 |year=2004 |pmid=15078215 |doi= 10.2174/1568026043450998|url=}} 4. ^{{cite journal |vauthors=Hutchinson SA, Scammells PJ |title=A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential |journal=Current Pharmaceutical Design |volume=10 |issue=17 |pages=2021–2039 |year=2004 |pmid=15279543 |doi= 10.2174/1381612043384204|url=}} 5. ^{{cite journal |vauthors=Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J |title=N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists |journal=Bioorganic & Medicinal Chemistry Letters |volume=17 |issue=1 |pages=161–166 |date=January 2007 |pmid=17045477 |doi=10.1016/j.bmcl.2006.09.065 |url=}} 6. ^{{cite journal |vauthors=Elzein E, Zablocki J |title=A1 adenosine receptor agonists and their potential therapeutic applications |journal=Expert Opinion on Investigational Drugs |volume=17 |issue=12 |pages=1901–1910 |date=December 2008 |pmid=19012505 |doi=10.1517/13543780802497284 |url=}} 7. ^{{cite journal |vauthors=Franchetti P, Cappellacci L, Vita P, Petrelli R, Lavecchia A, Kachler S, Klotz KN, Marabese I, Luongo L, Maione S, Grifantini M |title=N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice |journal=Journal of Medicinal Chemistry |volume=52 |issue=8 |pages=2393–2406 |date=April 2009 |pmid=19317449 |doi=10.1021/jm801456g |url=}} 3 : Nucleosides|Purines|Adenosine receptor agonists |
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