“N-acetylneuraminate 7-O(or 9-O)-acetyltransferase”的意思、由来-开放百科全书

词条

N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

释义

Nomenclature
References

{{enzyme
| Name = N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
| EC_number = 2.3.1.45
| CAS_number = 9054-50-6
| IUBMB_EC_number = 2/3/1/45
| GO_code = 0047186
| image =
| width =
| caption =
}}

In enzymology, a N-acetylneuraminate 7-O(or 9-O)-acetyltransferase ({{EC number|2.3.1.45}}) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + N-acetylneuraminate CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate

Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its 3 products are CoA, N-acetyl-7-O-acetylneuraminate, and N-acetyl-9-O-acetylneuraminate.

Nomenclature

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase. Other names in common use include N-acetylneuraminate 7(8)-O-acetyltransferase, sialate O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, glycoprotein 7(9)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, and acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase.

References

{{cite journal | vauthors = Schauer R | title = [Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse] | journal = Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie | volume = 351 | issue = 5 | pages = 595–602 | date = May 1970 | pmid = 5446640 }}
{{cite journal | vauthors = Schauer R | title = [Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase] | journal = Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie | volume = 351 | issue = 6 | pages = 749–58 | date = June 1970 | pmid = 5425947 | doi = 10.1515/bchm2.1970.351.1.749 }}

2 : EC 2.3.1|Enzymes of unknown structure

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