| 词条 | NACHT domain |
| 释义 |
| Symbol = NACHT | Name = NACHT domain | image = | width = | caption = | Pfam= PF05729 | InterPro= IPR007111 | SMART= | Prosite = PS50837 | SCOP = | TCDB = | OPM family= | OPM protein= | PDB= }} The NACHT domain is an evolutionarily conserved protein domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription.[1] Its name reflects some of the proteins that contain it: NAIP (NLP family apoptosis inhibitor protein), CIITA (that is, C2TA or MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TEP1 (that is, TP1 or telomerase-associated protein). The NACHT domain contains 300 to 400 amino acids. It is a predicted nucleoside-triphosphatase (NTPase) domain, which is found in animal, fungal and bacterial proteins. It is found in association with other domains, such as the CARD domain ({{InterPro|IPR001315}}), the pyrin domain ({{InterPro|IPR004020}}), the HEAT repeat domain ({{InterPro|IPR004155}}), the WD40 repeat ({{InterPro|IPR001680}}), the leucine-rich repeat (LRR) or the BIR repeat ({{InterPro|IPR001370}}).[1] The NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg2+-binding site (Walker A and B motifs, respectively) and five more specific motifs. The unique features of the NACHT domain include the prevalence of 'tiny' residues (glycine, alanine or serine) directly C-terminal of the Mg2+-coordinating aspartate in the Walker B motif, in place of a second acidic residue prevalent in other NTPases. A second acidic residue is typically found in the NACHT-containing proteins two positions downstream. Furthermore, the distal motif VII contains a conserved pattern of polar, aromatic and hydrophobic residues that is not seen in any other NTPase family.[1] ExamplesHuman proteins containing this domain include:
References1. ^1 2 {{cite journal | vauthors = Koonin EV, Aravind L | title = The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation | journal = Trends in Biochemical Sciences | volume = 25 | issue = 5 | pages = 223–4 | date = May 2000 | pmid = 10782090 | doi = 10.1016/S0968-0004(00)01577-2 }} {{protein-stub}}{{Protein domains}}{{InterPro content|IPR007111}} 1 : Protein domains |
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