“NAD+ diphosphatase”的意思、由来-开放百科全书

词条

NAD+ diphosphatase

释义

Structural studies
References

{{enzyme
| Name = NAD⁺ diphosphatase
| EC_number = 3.6.1.22
| CAS_number = 37289-33-1
| IUBMB_EC_number = 3/6/1/22
| GO_code = 0000210
| image =
| width =
| caption =
}}

In enzymology, a NAD⁺ diphosphatase ({{EC number|3.6.1.22}}) is an enzyme that catalyzes the chemical reaction

NAD⁺ + H₂O AMP + NMN

Thus, the two substrates of this enzyme are NAD⁺ and H₂O, whereas its two products are AMP and NMN.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is NAD⁺ phosphohydrolase. Other names in common use include nicotinamide adenine dinucleotide pyrophosphatase, NADP+ pyrophosphatase, and NADH pyrophosphatase. This enzyme participates in nicotinate and nicotinamide metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|2GB5}}.

References

{{cite journal | vauthors = Anderson BM, Lang CA | date = 1966 | title = Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito | journal = Biochem. J. | volume = 101 | pages = 392–6 | pmid = 4381708 | issue = 2 | pmc = 1270119 }}
{{cite journal | vauthors = Nakajima Y, Fukunaga N, Sasaki S, Usami S | date = 1973 | title = Purification and properties of NADP pyrophosphatase from Proteus vulgaris | journal = Biochim. Biophys. Acta | volume = 293 | pages = 242–55 | pmid = 4405504 | issue = 1 | doi=10.1016/0005-2744(73)90397-5}}

3 : EC 3.6.1|NADH-dependent enzymes|Enzymes of known structure

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