| 词条 | Naltriben |
| 释义 |
| verifiedrevid = 444022443 | IUPAC_name = | image = Naltriben.svg | alt = Skeletal formula | width = 215 | image2 = Naltriben molecule ball.png | alt2 = Ball-and-stick model of naltriben | tradename = | routes_of_administration = | metabolism = | excretion = | CAS_number = 111555-58-9 | ATC_prefix = none | PubChem = 5486827 | IUPHAR_ligand = 1640 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4589081 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 100940 | C=26 | H=25 | N=1 | O=4 | molecular_weight = 415.480 g/mol | smiles = Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZHVWWEYETMPAMX-IFKAHUTRSA-N }}Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2] See also
References1. ^Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. {{PMID|1851833}} {{Opioidergics}}2. ^Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. {{PMID|8028443}} 6 : Opioid antagonists|Phenols|Alcohols|Kappa agonists|Semisynthetic opioids|Morphinans |
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