| 词条 | Napoleone Ferrara |
| 释义 |
| name = | native_name = | native_name_lang = | image = | image_size = | caption = | birth_date = {{birth date |df=yes|1956|07|26}} | birth_place = | death_date = | death_place = | death_cause = | citizenship = | nationality = | fields = | workplaces = {{plainlist|
}} | education = | alma_mater = {{plainlist|
}} | known_for = VEGF discovery | awards = {{plainlist|
}} | spouse = | children = }}{{BLP sources|date=January 2009}} Napoleone Ferrara (born 26 July 1956, Catania), is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy.[1] At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available angiogenesis inhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers.{{fact|date=December 2017}} Ferrara's work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders.{{fact|date=December 2017}} EducationFerrara received his medical degree from the University of Catania, Italy, in 1981, and joined Genentech in 1988. He did his postdoctoral research at University of California, San Francisco.[2] Current researchAt UC San Diego Moores Cancer Center, Ferrara, a member of the National Academy of Sciences since 2006, serves as Senior Deputy Director for Basic Science and is a Distinguished Professor of Pathology in the UC San Diego School of Medicine, where he will continue cancer drug research targeting angiogenesis.{{fact|date=December 2017}} He is presently focusing on investigating mechanisms of tumor angiogenesis alternative to VEGF, in particular the role of factors produced by myeloid cells and fibroblasts in mediating resistance to VEGF inhibitors.{{fact|date=December 2017}} Selected honors and awardsFor his VEGF discovery, he won a Lasker Award in 2010.[3] In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work.[4] He has received numerous other awards, including the General Motors Cancer Research Award (2006), the ASCO Science of Oncology Award (2007), the Pezcoller Foundation/AACR International Award (2009), the Dr. Paul Janssen Award for Biomedical Research (2011), and The Economist's Innovation Award for bioscience in 2012.{{fact|date=December 2017}} Grand Prix scientifique de la Fondation Lefoulon-Delalande in 2005.[5] In September 2014, Ferrara was awarded the António Champalimaud Vision Award, awarded by the Champalimaud Foundation.[6] References1. ^{{cite web|title=Napoleone Ferrara, MD: Senior Deputy Director, Basic Science; Distinguished Professor of Pathology|url=https://healthsciences.ucsd.edu/research/moores/about/leadership/directors-office/Pages/basic-science.aspx|website=UC San Diego Health Sciences|accessdate=8 June 2016}} {{Breakthrough Prize laureates}}{{Authority control}}{{DEFAULTSORT:Ferrara, Napoleone}}{{italy-biologist-stub}}2. ^[https://archive.today/20120910044955/http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T64-4FYG6N7-5&_user=4429&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000059602&_version=1&_urlVersion=0&_userid=4429&md5=0c53e7083cf75f478bba859312458ba4 Napoleone Ferrara discusses Avastin and the future of anti-angiogenesis therapy], ScienceDirect. 3. ^{{cite web |url=http://www.laskerfoundation.org/awards/2010_c_description.htm |title=2010 Winners - Lasker~DeBakey Clinical Medical Research Award |author=Strauss, Evelyn |publisher=The Lasker Foundation |accessdate=2010-11-11}} 4. ^http://breakthroughprizeinlifesciences.org/news1 5. ^{{Cite news|url=http://lefoulon-delalande.institut-de-france.fr/historique-0#12_le_grand_prix_scientifique_2005|title=Historique|date=2012-04-12|work=Fondation Lefoulon-Delalande Institut de France|access-date=2017-12-12}} 6. ^Ferrara Receives Champalimaud Award for Role in Eye Disease Therapy, UC San Diego 11 : 1956 births|Living people|Italian molecular biologists|Italian scientists|Molecular biologists|Genentech people|University of California, San Diego faculty|Winners of The Economist innovation awards|Recipients of the Lasker-DeBakey Clinical Medical Research Award|University of California, San Francisco alumni|Breakthrough Prize winners |
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