释义 |
- References
- Further reading
{{Infobox_gene}}Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.[1][2][3]NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM][3] References1. ^{{cite journal | vauthors = Hazra TK, Kow YW, Hatahet Z, Imhoff B, Boldogh I, Mokkapati SK, Mitra S, Izumi T | title = Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions | journal = J Biol Chem | volume = 277 | issue = 34 | pages = 30417–20 |date=Aug 2002 | pmid = 12097317 | pmc = | doi = 10.1074/jbc.C200355200 }} 2. ^{{cite journal | vauthors = Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK | title = Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress | journal = J Biol Chem | volume = 282 | issue = 39 | pages = 28474–84 |date=Sep 2007 | pmid = 17686777 | pmc = 2679419 | doi = 10.1074/jbc.M704672200 }} 3. ^1 {{cite web | title = Entrez Gene: NEIL2 nei like 2 (E. coli)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=252969| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
- {{cite journal |vauthors=Takao M, Kanno S, Kobayashi K, etal |title=A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42205–13 |year= 2003 |pmid= 12200441 |doi= 10.1074/jbc.M206884200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal | vauthors=Bandaru V, Sunkara S, Wallace SS, Bond JP |title=A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. |journal=DNA Repair (Amst.) |volume=1 |issue= 7 |pages= 517–29 |year= 2003 |pmid= 12509226 |doi=10.1016/S1568-7864(02)00036-8 }}
- {{cite journal | vauthors=Dou H, Mitra S, Hazra TK |title=Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49679–84 |year= 2004 |pmid= 14522990 |doi= 10.1074/jbc.M308658200 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Katafuchi A, Nakano T, Masaoka A, etal |title=Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 14464–71 |year= 2004 |pmid= 14734554 |doi= 10.1074/jbc.M400393200 }}
- {{cite journal | vauthors=Bhakat KK, Hazra TK, Mitra S |title=Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. |journal=Nucleic Acids Res. |volume=32 |issue= 10 |pages= 3033–9 |year= 2004 |pmid= 15175427 |doi= 10.1093/nar/gkh632 | pmc=434438 }}
- {{cite journal |vauthors=Das A, Rajagopalan L, Mathura VS, etal |title=Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47132–8 |year= 2004 |pmid= 15339932 |doi= 10.1074/jbc.M406224200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
- {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
- {{cite journal |vauthors=Das A, Wiederhold L, Leppard JB, etal |title=NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. |journal=DNA Repair (Amst.) |volume=5 |issue= 12 |pages= 1439–48 |year= 2007 |pmid= 16982218 |doi= 10.1016/j.dnarep.2006.07.003 | pmc=2805168 }}
- {{cite journal |vauthors=Broderick P, Bagratuni T, Vijayakrishnan J, etal |title=Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition. |journal=BMC Cancer |volume=6 |issue= |pages= 243 |year= 2006 |pmid= 17029639 |doi= 10.1186/1471-2407-6-243 | pmc=1624846 }}
- {{cite journal |vauthors=Katafuchi A, Matsubara M, Terato H, etal |title=Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions. |journal=Nucleic Acids Symp Ser (Oxf) |volume= 48|issue= 48 |pages= 175–6 |year= 2007 |pmid= 17150535 |doi= 10.1093/nass/48.1.175 }}
{{refend}}{{gene-8-stub}} 1 : Human proteins |