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词条 NEK2
释义

  1. Interactions

  2. References

  3. Further reading

{{Infobox_gene}}Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.[1][2]

Interactions

NEK2 has been shown to interact with MAPK1[3] and NDC80.[4][5]

Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not [Uniprot].

References

1. ^{{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth Differ | volume = 4 | issue = 10 | pages = 821–30 | date = Feb 1994 | pmid = 8274451 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4751| accessdate = }}
3. ^{{cite journal | vauthors = Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB | title = Nek2A specifies the centrosomal localization of Erk2 | journal = Biochem. Biophys. Res. Commun. | volume = 321 | issue = 2 | pages = 495–501 | date = Aug 2004 | pmid = 15358203 | doi = 10.1016/j.bbrc.2004.06.171 }}
4. ^{{cite journal | vauthors = Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH | title = Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49408–16 | date = Dec 2002 | pmid = 12386167 | doi = 10.1074/jbc.M207069200 }}
5. ^{{cite journal | vauthors = Chen Y, Sharp ZD, Lee WH | title = HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins | journal = J. Biol. Chem. | volume = 272 | issue = 38 | pages = 24081–7 | date = Sep 1997 | pmid = 9295362 | doi = 10.1074/jbc.272.38.24081 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Hayward DG, Fry AM | title = Nek2 kinase in chromosome instability and cancer. | journal = Cancer Lett. | volume = 237 | issue = 2 | pages = 155–66 | year = 2006 | pmid = 16084011 | doi = 10.1016/j.canlet.2005.06.017 }}
  • {{cite journal | vauthors = Schultz SJ, Fry AM, Sütterlin C, Ried T, Nigg EA | title = Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. | journal = Cell Growth Differ. | volume = 5 | issue = 6 | pages = 625–35 | year = 1994 | pmid = 7522034 | doi = }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Fry AM, Meraldi P, Nigg EA | title = A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators | journal = EMBO J. | volume = 17 | issue = 2 | pages = 470–81 | year = 1998 | pmid = 9430639 | pmc = 1170398 | doi = 10.1093/emboj/17.2.470 }}
  • {{cite journal | vauthors = Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA | title = C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 | journal = J. Cell Biol. | volume = 141 | issue = 7 | pages = 1563–74 | year = 1998 | pmid = 9647649 | pmc = 2133000 | doi = 10.1083/jcb.141.7.1563 }}
  • {{cite journal | vauthors = Fry AM, Arnaud L, Nigg EA | title = Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif | journal = J. Biol. Chem. | volume = 274 | issue = 23 | pages = 16304–10 | year = 1999 | pmid = 10347187 | doi = 10.1074/jbc.274.23.16304 }}
  • {{cite journal | vauthors = Schutte BC, Bjork BC, Coppage KB, Malik MI, Gregory SG, Scott DJ, Brentzell LM, Watanabe Y, Dixon MJ, Murray JC | title = A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41 | journal = Genome Res. | volume = 10 | issue = 1 | pages = 81–94 | year = 2000 | pmid = 10645953 | pmc = 310500 | doi = 10.1101/gr.10.1.81 | doi-broken-date = 2018-11-07 }}
  • {{cite journal | vauthors = Helps NR, Luo X, Barker HM, Cohen PT | title = NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 | journal = Biochem. J. | volume = 349 | issue = Pt 2 | pages = 509–18 | year = 2001 | pmid = 10880350 | pmc = 1221174 | doi = 10.1042/0264-6021:3490509 }}
  • {{cite journal | vauthors = Hames RS, Fry AM | title = Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis | journal = Biochem. J. | volume = 361 | issue = Pt 1 | pages = 77–85 | year = 2002 | pmid = 11742531 | pmc = 1222281 | doi = 10.1042/0264-6021:3610077 }}
  • {{cite journal | vauthors = Ha Kim Y, Yeol Choi J, Jeong Y, Wolgemuth DJ, Rhee K | title = Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle | journal = Biochem. Biophys. Res. Commun. | volume = 290 | issue = 2 | pages = 730–6 | year = 2002 | pmid = 11785960 | doi = 10.1006/bbrc.2001.6212 }}
  • {{cite journal | vauthors = Eto M, Elliott E, Prickett TD, Brautigan DL | title = Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation | journal = J. Biol. Chem. | volume = 277 | issue = 46 | pages = 44013–20 | year = 2003 | pmid = 12221103 | doi = 10.1074/jbc.M208035200 }}
  • {{cite journal | vauthors = Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH | title = Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49408–16 | year = 2003 | pmid = 12386167 | doi = 10.1074/jbc.M207069200 }}
  • {{cite journal | vauthors = Faragher AJ, Fry AM | title = Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles | journal = Mol. Biol. Cell | volume = 14 | issue = 7 | pages = 2876–89 | year = 2004 | pmid = 12857871 | pmc = 165683 | doi = 10.1091/mbc.E03-02-0108 }}
  • {{cite journal | vauthors = Lou Y, Yao J, Zereshki A, Dou Z, Ahmed K, Wang H, Hu J, Wang Y, Yao X | title = NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling | journal = J. Biol. Chem. | volume = 279 | issue = 19 | pages = 20049–57 | year = 2004 | pmid = 14978040 | doi = 10.1074/jbc.M314205200 }}
  • {{cite journal | vauthors = Noguchi K, Fukazawa H, Murakami Y, Uehara Y | title = Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells | journal = J. Biol. Chem. | volume = 279 | issue = 31 | pages = 32716–27 | year = 2004 | pmid = 15161910 | doi = 10.1074/jbc.M404104200 }}
  • {{cite journal | vauthors = Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM | title = Lineage-specific gene duplication and loss in human and great ape evolution | journal = PLoS Biol. | volume = 2 | issue = 7 | pages = E207 | year = 2006 | pmid = 15252450 | pmc = 449870 | doi = 10.1371/journal.pbio.0020207 }}
  • {{cite journal | vauthors = Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB | title = Nek2A specifies the centrosomal localization of Erk2 | journal = Biochem. Biophys. Res. Commun. | volume = 321 | issue = 2 | pages = 495–501 | year = 2004 | pmid = 15358203 | doi = 10.1016/j.bbrc.2004.06.171 }}
{{refend}}{{PDB Gallery|geneid=4751}}{{gene-1-stub}}

1 : Human proteins

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