The following railroads operate in the U.S. state of Missouri.
| Name | Mark | System[1] | From | To | Successor | Notes |
|---|
| Adair County Railroad | CB&Q | 1904 | 1911 | Chicago, Burlington and Quincy Railroad |
| Alexandria and Bloomfield Railroad | CB&Q | 1857 | 1866 | Alexandria and Nebraska City Railroad |
| Alexandria, Canton, La Grange and West Quincy Railroad | CB&Q | 1865 | 1870 | Mississippi and Missouri River Air Line Railroad |
| Alexandria and Nebraska City Railroad | CB&Q | 1866 | 1870 | Missouri, Iowa and Nebraska Railway |
| Alton Railroad | A | GM&O | 1931 | 1947 | Gulf, Mobile and Ohio Railroad |
| Arkansas Railroad | SLSF | 1901 | 1901 | Southern Missouri and Arkansas Railroad |
| Arkansas and Ozarks Railway | 1950 | 1961 | N/A |
| Atchison Branch of the Chicago and South Western Railway | RI | 1870 | 1871 | Chicago and South Western Railway |
| Atchison and Eastern Bridge Company | 1898 | |
| Atchison and Nebraska Railroad | CB&Q | 1871 | 1908 | Chicago, Burlington and Quincy Railroad |
| Atchison and St. Joseph Railroad | CB&Q | 1855 | 1867 | Missouri Valley Railroad |
| Atchison, Topeka and Santa Fe Railroad | ATSF | 1875 | 1895 | Atchison, Topeka and Santa Fe Railway |
| Atchison, Topeka and Santa Fe Railway | ATSF | ATSF | 1895 | 1996 | BNSF Railway |
| Atlantic and Pacific Railroad | SLSF | 1866 | 1878 | St. Louis and San Francisco Railway |
| Baltimore and Ohio Railroad | B&O, BO | B&O | 1900 | 1987 | Chesapeake and Ohio Railway |
| Baltimore and Ohio Southwestern Railroad | B&O | 1899 | 1900 | Baltimore and Ohio Railroad |
| Baltimore and Ohio Southwestern Railway | B&O | 1893 | 1899 | Baltimore and Ohio Southwestern Railroad |
| Bellevue Valley Railroad |
| Bennett and Cook Southeastern Railroad |
| Bevier and Southern Railroad | BV&S, BVS | 1914 | | N/A |
| Blytheville, Leachville and Arkansas Southern Railroad | SSW | 1908 | 1929 | St. Louis Southwestern Railway |
| Boone County and Boonville Railway | WAB | 1873 | 1902 | Columbia and St. Louis Railroad |
| Boone County and Jefferson City Railroad | WAB | 1857 | 1873 | Boone County and Boonville Railway |
| Boonville Railroad Bridge Company | MKT | 1870 | 1925 | Missouri–Kansas–Texas Railroad |
| Boonville, St. Louis and Southern Railway | MP | 1878 | 1956 | Missouri Pacific Railroad |
| Brownville and Nodaway Valley Railway | CB&Q | 1872 | 1901 | Chicago, Burlington and Quincy Railroad |
| Brownwood and Northwestern Railway | SLSF | 1886 | 1898 | Cape Girardeau, Bloomfield and Southern Railway |
| Brunswick and Chillicothe Railroad | WAB | 1873 | 1924 | Wabash Railway |
| Burlington Northern Inc. | BN | 1970 | 1981 | Burlington Northern Railroad |
| Burlington Northern Railroad | BN | 1981 | 1996 | Burlington Northern and Santa Fe Railway |
| Burlington and Southwestern Railway | CB&Q | 1871 | 1880 | Chicago, Burlington and Kansas City Railway |
| Butler County Railroad | BLC | SLSF | 1905 | 1950 | St. Louis – San Francisco Railway |
| Cairo, Arkansas and Texas Railroad | MP | 1872 | 1874 | St. Louis, Iron Mountain and Southern Railway |
| Cairo and Fulton Railroad | MP | 1854 | 1866 | Cairo, Arkansas and Texas Railroad |
| Campbell and St. Francis Valley Railway |
| Canton and Bloomfield Railroad | CB&Q | 1851 | 1860 | Mississippi and Missouri River Air Line Railroad |
| Cape Girardeau Railway | SLSF | 1880 | 1881 | Cape Girardeau Southwestern Railway |
| Cape Girardeau, Bloomfield and Southern Railway | SLSF | 1887 | 1902 | St. Louis and Gulf Railway |
| Cape Girardeau and Chester Railroad | 1902 | 1913 | Cape Girardeau Northern Railway |
| Cape Girardeau and Northern Railroad | SLSF | 1901 | 1902 | St. Louis, Memphis and Southeastern Railroad |
| Cape Girardeau Northern Railway | 1913 | 1937 | N/A |
| Cape Girardeau Southwestern Railway | SLSF | 1881 | 1891 | St. Louis, Cape Girardeau and Fort Smith Railway |
| Cape Girardeau and State Line Railway | SLSF | 1869 | 1880 | Cape Girardeau Railway |
| Cape Girardeau and Thebes Bridge Terminal Railroad | 1902 | 1913 | Cape Girardeau Northern Railway |
| Carthage, Joplin and Short Creek Railway | MP | 1881 | 1883 | Missouri Pacific Railway |
| Carthage and Western Railway | MP | 1902 | 1910 | Missouri Pacific Railway |
| Cassville and Exeter Railway | 1919 | 1956 | N/A |
| Cassville and Western Railroad | 1913 | 1919 | Cassville and Exeter Railway |
| Cassville and Western Railway | 1896 | 1913 | Cassville and Western Railroad |
| Central Railway of Missouri | RI | 1881 | 1883 | St. Louis and Central Missouri Railway |
| Central Missouri Railway | MKT | 1885 | 1888 | Cleveland, St. Louis and Kansas City Railway |
| Central North Missouri Branch of the St. Joseph and Iowa Railroad | CB&Q | 1871 | 1871 | Linneus Branch of the Burlington and Southwestern Railway |
| Chariton and Randolph Railroad | WAB | 1858 | 1864 | North Missouri Railroad |
| Chesapeake and Ohio Railway | CO | 1987 | 1987 | CSX Transportation |
| Chester, Perryville and Ste. Genevieve Railway | 1899 | 1913 | Cape Girardeau Northern Railway |
| Chester, Perryville, Ste. Genevieve and Farmington Railroad | 1894 | 1899 | Chester, Perryville and Ste. Genevieve Railway |
| Chicago and Alton Railroad | C&A | GM&O | 1870 | 1931 | Alton Railroad |
| Chicago and Atchison Bridge Company | | 1898 | Atchison and Eastern Bridge Company |
| Chicago, Burlington and Kansas City Railway | CB&Q | 1881 | 1901 | Chicago, Burlington and Quincy Railroad |
| Chicago, Burlington and Quincy Railroad | CB&Q, CBQ | CB&Q | 1869 | 1970 | Burlington Northern Inc. |
| Chicago, Burlington and Quincy Railway | CB&Q | 1901 | 1907 | N/A | Operated the Chicago, Burlington and Quincy Railroad under lease, but did not own any railroad |
| Chicago and Eastern Illinois Railroad | C&EI, CEI | C&EI | 1940 | 1976 | Missouri Pacific Railroad |
| Chicago and Eastern Illinois Railroad | C&EI | 1904 | 1922 | Chicago and Eastern Illinois Railway |
| Chicago and Eastern Illinois Railway | C&EI | C&EI | 1922 | 1940 | Chicago and Eastern Illinois Railroad |
| Chicago Great Western Railroad | CGW | CGW | 1909 | 1941 | Chicago Great Western Railway |
| Chicago Great Western Railway | CGW | CGW | 1941 | 1968 | Chicago and North Western Railway |
| Chicago Great Western Railway | CGW | 1892 | 1909 | Chicago Great Western Railroad |
| Chicago, Kansas and Nebraska Railway | RI | 1886 | 1891 | Chicago, Rock Island and Pacific Railway |
| Chicago, Kansas City and Texas Railway | CB&Q | 1887 | 1893 | Kansas City and Atlantic Railroad |
| Chicago, Milwaukee and St. Paul Railway | MILW | 1874 | 1928 | Chicago, Milwaukee, St. Paul and Pacific Railroad |
| Chicago, Milwaukee, St. Paul and Pacific Railroad | MILW | MILW | 1928 | 1985 | The Milwaukee Road, Inc. |
| Chicago, Missouri and Western Railway | CMNW | 1987 | 1990 | Gateway Western Railway |
| Chicago and North Western Railway | CNW | CNW | 1968 | 1972 | Chicago and North Western Transportation Company |
| Chicago and North Western Transportation Company | CNW | CNW | 1972 | 1995 | Union Pacific Railroad |
| Chicago, Rock Island and Pacific Railroad | RI, ROCK | RI | 1948 | 1980 | Atchison, Topeka and Santa Fe Railway, Chicago and North Western Transportation Company, St. Louis Southwestern Railway |
| Chicago, Rock Island and Pacific Railway | RI | RI | 1880 | 1948 | Chicago, Rock Island and Pacific Railroad |
| Chicago, St. Paul and Kansas City Railway | CGW | 1886 | 1893 | Chicago Great Western Railway |
| Chicago, Santa Fe and California Railway | ATSF | 1887 | 1900 | Atchison, Topeka and Santa Fe Railway |
| Chicago, Santa Fe and California Railway of Iowa | ATSF | 1886 | 1887 | Chicago, Santa Fe and California Railway |
| Chicago and South Western Railway | RI | 1869 | 1878 | Iowa Southern and Missouri Northern Railroad |
| Chillicothe and Brunswick Railroad | WAB | 1864 | 1873 | Brunswick and Chillicothe Railroad |
| Chillicothe–Brunswick Rail Maintenance Authority | CBRM | 1986 | 2007 | Missouri North Central Railroad |
| Chillicothe and Des Moines City Railroad |
| Chillicothe and Omaha Railroad | WAB | 1869 | 1870 | St. Louis, Council Bluffs and Omaha Railroad |
| Chillicothe Southern Railroad | CHSR | 1986 | 1986 | Chillicothe–Brunswick Rail Maintenance Authority |
| City Terminal Railway | CGW | 1899 | 1905 | Chicago Great Western Railway |
| Clarinda and St. Louis Railroad | WAB | 1879 | 1879 | St. Louis, Kansas City and Northern Railway |
| Clarksville and Western Railroad | CB&Q | 1870 | 1873 | Mississippi Valley and Western Railway |
| Cleveland, Cincinnati, Chicago and St. Louis Railway | NYC | 1889 | 1930 | New York Central Railroad |
| Cleveland, St. Louis and Kansas City Railway | MKT | 1888 | 1890 | Missouri, Kansas and Eastern Railway |
| Columbia and St. Louis Railroad | WAB | 1902 | 1902 | Wabash Railroad |
| Consolidated Rail Corporation | CR | 1976 | 1999 | CSX Transportation |
| Consolidated Terminal Railway of Kansas City | KCS | 1891 | 1892 | Kansas City Suburban Belt Railroad |
| Council Bluffs and St. Louis Railroad | WAB | 1878 | 1879 | St. Louis, Kansas City and Northern Railway |
| Crawford County Midland Railroad | SLSF | 1904 | 1907 | St. Louis and San Francisco Railroad |
| Crystal Railway | SLSF | 1880 | 1902 | St. Louis, Memphis and Southeastern Railroad |
| Crystal City Railway | SLSF | 1878 | 1881 | Crystal Railway |
| Current River Railroad | SLSF | 1887 | 1901 | Kansas City, Fort Scott and Memphis Railway |
| Deering Southwestern Railway | DSW | SSW | 1903 | 1929 | St. Louis Southwestern Railway |
| Dent and Phelps Railroad | SLSF | 1877 | 1881 | St. Louis, Salem and Little Rock Railroad |
| Des Moines and Kansas City Railway | CB&Q | 1888 | 1898 | Missouri, Iowa and Nebraska Railway |
| Des Moines, Osceola and Southern Railroad | CB&Q | 1879 | 1887 | Des Moines and Kansas City Railway |
| Des Peres Valley Railway |
| Doniphan Branch Railway | MP | 1882 | 1884 | St. Louis, Iron Mountain and Southern Railway |
| Edgewater Terminal Railroad | MP | 1900 | | |
| Eureka Springs Railway | 1882 | 1899 | St. Louis and North Arkansas Railway |
| Excelsior Springs Railroad | WAB | 1893 | 1897 | Kansas City, Excelsior Springs and Northern Railway |
| Forest Park and Central Railroad | RI | 1877 | 1884 | St. Louis, Kansas City and Colorado Railroad |
| Fort Scott and Carthage Railroad | SLSF | 1881 | 1882 | Kansas and Missouri Railroad |
| Fort Scott, South Eastern and Memphis Railroad | SLSF | 1880 | 1888 | Kansas City, Fort Scott and Springfield Railroad |
| Gateway Western Railway | GWWR | 1990 | 2001 | Kansas City Southern Railway |
| Gideon and North Island Railroad | SSW | 1908 | 1930 | St. Louis Southwestern Railway |
| Grant City and Southern Railroad | CB&Q | 1898 | 1901 | Chicago, Burlington and Quincy Railroad |
| Gray's Point Terminal Railway | SSW | 1896 | 1958 | St. Louis Southwestern Railway |
| Greenfield Railroad | SLSF | 1884 | 1886 | Greenfield and Northern Railroad |
| Greenfield and Northern Railroad | SLSF | 1886 | 1895 | Kansas City, Fort Scott and Memphis Railroad |
| Gulf, Mobile and Ohio Railroad | GM&O | 1940 | 1972 | Illinois Central Gulf Railroad |
| Hamilton and Kingston Railroad |
| Hannibal Bridge Company | WAB | 1869 | 1937 | Wabash – Hannibal Bridge Company |
| Hannibal Connecting Railroad | HC | 1902 | 1965 | N/A |
| Hannibal and Central Missouri Railroad | MKT | 1867 | 1873 | Missouri, Kansas and Texas Railway |
| Hannibal and St. Joseph Railroad | CB&Q | 1847 | 1901 | Chicago, Burlington and Quincy Railroad |
| Hannibal Union Depot Company | CB&Q | 1881 | 1953 | Chicago, Burlington and Quincy Railroad |
| Higginsville Switch Company |
| Houck's Missouri and Arkansas Railroad | SLSF | 1893 | 1902 | St. Louis and Gulf Railway |
| Illinois Central Railroad | IC | IC | 1902 | 1972 | Illinois Central Gulf Railroad |
| Illinois Central Gulf Railroad | ICG | 1972 | |
| Illinois and St. Louis Bridge Company | 1868 | 1878 | St. Louis Bridge Company |
| Illinois Southern Railway | MP | 1903 | 1920 | Missouri–Illinois Railroad |
| I&M Rail Link | IMRL | 1997 | 2002 | Iowa, Chicago and Eastern Railroad |
| Iron County Central Railroad | 1912 | |
| Iowa, Chicago and Eastern Railroad | ICE | 2002 | 2008 | Dakota, Minnesota and Eastern Railroad |
| Iowa and St. Louis Railway | CB&Q | 1901 | 1903 | Chicago, Burlington and Quincy Railroad |
| Iowa Southern and Missouri Northern Railroad | RI | 1876 | 1880 | Chicago, Rock Island and Pacific Railway |
| Jackson Branch Railroad | MP | 1883 | 1885 | St. Louis, Iron Mountain and Southern Railway |
| Jefferson City, Lebanon and Southwestern Railway | MP | 1871 | 1883 | Missouri Pacific Railway |
| Joplin Railroad | SLSF | 1874 | 1882 | Joplin Railway |
| Joplin Railway | SLSF | 1882 | 1882 | St. Louis and San Francisco Railway |
| Joplin and Galena Railway | SLSF | 1880 | 1882 | Joplin Railway |
| Joplin Union Depot Company | ATSF/ KCS/ MKT | 1908 | Still exists as a joint subsidiary of the BNSF Railway, Kansas City Southern Railway, and Union Pacific Railroad |
| Joplin and Western Railway | MP | 1890 | 1910 | Missouri Pacific Railway |
| Kansas City and Atlantic Railroad | CB&Q | 1893 | 1897 | Kansas City and Northern Connecting Railroad |
| Kansas City Belt Railway | 1882 | 1910 | Kansas City Terminal Railway |
| Kansas City Bridge and Terminal Railway | CB&Q | 1889 | 1893 | Kansas City and Atlantic Railroad |
| Kansas City and Cameron Railroad | CB&Q | 1866 | 1870 | Hannibal and St. Joseph Railroad |
| Kansas City, Clinton and Springfield Railroad | SLSF | 1884 | 1885 | Kansas City, Clinton and Springfield Railway |
| Kansas City, Clinton and Springfield Railway | SLSF | 1885 | 1928 | St. Louis – San Francisco Railway |
| Kansas City Connecting Railroad | KCC | 1914 | 1983 | N/A |
| Kansas City and Eastern Railway | MP | 1878 | 1880 | Missouri Pacific Railway |
| Kansas City, Eldorado and Southern Railway | MKT | 1892 | 1899 | Missouri, Kansas and Texas Railway |
| Kansas City, Excelsior Springs and Northern Railway | WAB | 1897 | 1933 | N/A |
| Kansas City, Fort Scott and Gulf Railroad | SLSF | 1879 | 1888 | Kansas City, Fort Scott and Memphis Railroad |
| Kansas City, Fort Scott and Memphis Railroad | SLSF | 1888 | 1901 | Kansas City, Fort Scott and Memphis Railway |
| Kansas City, Fort Scott and Memphis Railway | SLSF | 1901 | 1928 | St. Louis – San Francisco Railway |
| Kansas City, Fort Scott and Springfield Railroad | SLSF | 1888 | 1888 | Kansas City, Fort Scott and Memphis Railroad |
| Kansas City, Fort Smith and Southern Railroad | KCS | 1887 | 1897 | Kansas City, Pittsburg and Gulf Railroad |
| Kansas City, Galveston, and Lake Superior Railroad | CB&Q | 1857 | 1866 | Kansas City and Cameron Railroad |
| Kansas City and Grandview Railway | KCS | 1926 | 1943 | Kansas City Southern Railway |
| Kansas City and Independence Air Line | KCS | 1891 | 1902 | Kansas City Southern Railway |
| Kansas City, Leavenworth and Atchison Railway | MP | 1880 | 1880 | Missouri Pacific Railway |
| Kansas City and Memphis Railroad | SLSF | 1872 | 1879 | Springfield and Western Missouri Railroad |
| Kansas City, Memphis and Mobile Railroad | SLSF | 1871 | 1880 | Kansas City and Southern Railway |
| Kansas City, Nevada and Fort Smith Railroad | KCS | 1889 | 1893 | Kansas City, Pittsburg and Gulf Railroad |
| Kansas City and Northern Connecting Railroad | CB&Q | 1895 | 1901 | Kansas City, Peoria and Chicago Railway |
| Kansas City, Osceola and Southern Railway | SLSF | 1891 | 1900 | St. Louis and San Francisco Railroad |
| Kansas City, Ozark and Southern Railway | 1908 | 1935 | N/A |
| Kansas City, Peoria and Chicago Railway | CB&Q | 1901 | 1902 | Quincy, Omaha and Kansas City Railroad |
| Kansas City, Pittsburg and Gulf Railroad | KCS | 1893 | 1900 | Kansas City Southern Railway |
| Kansas City, Rich Hill and Southern Railroad | KCS | 1887 | 1890 | Kansas City, Nevada and Fort Smith Railroad |
| Kansas City Rock Island Railway | RI | 1902 | 1905 | Chicago, Rock Island and Pacific Railway |
| Kansas City, St. Joseph and Burlington Railway | CB&Q | 1881 | 1881 | Chicago, Burlington and Kansas City Railway |
| Kansas City, St. Joseph and Council Bluffs Railroad | CB&Q | 1870 | 1901 | Chicago, Burlington and Quincy Railroad |
| Kansas City, St. Louis and Chicago Railroad | GM&O | 1877 | 1949 | Gulf, Mobile and Ohio Railroad |
| Kansas City and Southern Railway | SLSF | 1880 | 1891 | Kansas City, Osceola and Southern Railway |
| Kansas City and Southwestern Railway of Missouri | MP | 1886 | 1909 | Missouri Pacific Railway |
| Kansas City, Springfield and Memphis Railroad | SLSF | 1881 | 1888 | Kansas City, Fort Scott and Memphis Railroad |
| Kansas City Suburban Belt Railroad | KCS | 1887 | 1902 | Kansas City Southern Railway |
| Kansas City and Topeka Railway | RI | 1887 | 1889 | Chicago, Rock Island and Pacific Railway |
| Kansas City, Topeka and Western Railroad | ATSF | 1875 | 1899 | Atchison, Topeka and Santa Fe Railway |
| Kansas and Missouri Railroad | SLSF | 1882 | 1888 | Kansas City, Fort Scott and Springfield Railroad |
| Kansas and Neosho Valley Railroad | SLSF | 1865 | 1868 | Missouri River, Fort Scott and Gulf Railroad |
| Kansas Pacific Railway | UP | 1869 | 1880 | Union Pacific Railway |
| Kansas and Texas Coal Company | 1898 | 1902 | Missouri and Louisiana Railroad |
| Kennett and Osceola Railroad | SLSF | 1896 | 1902 | St. Louis and Gulf Railway |
| Keokuk and Kansas City Railway | WAB | 1873 | 1875 | Salisbury and Glasgow Railroad |
| Keokuk and Western Railroad | CB&Q | 1886 | 1901 | Chicago, Burlington and Quincy Railroad |
| Laclede and Creve Coeur Lake Railroad | MP | 1880 | 1883 | Missouri Pacific Railway |
| Lawrence and Pleasant Hill Railway | SLSF | 1869 | 1870 | St. Louis, Lawrence and Denver Railroad |
| Lead Belt Railway | 1898 |
| Leavenworth and Des Moines Railway | RI | 1867 | 1869 | Chicago and South Western Railway |
| Leavenworth, Kansas and Western Railway | UP | 1897 | 1908 | Union Pacific Railroad |
| Leavenworth, Pawnee and Western Railroad | UP | 1855 | 1863 | Union Pacific Railway, Eastern Division |
| Leavenworth and Platte County Bridge Company | CGW | 1888 | 1892 | Leavenworth Terminal Railway and Bridge Company |
| Leavenworth and St. Joseph Railway | CGW | 1890 | 1892 | Chicago Great Western Railway |
| Leavenworth Terminal Railway and Bridge Company | CGW | 1892 | 1940 | Chicago Great Western Railroad |
| Leon, Mount Ayr and Southwestern Railroad | CB&Q | 1878 | 1901 | Chicago, Burlington and Quincy Railroad |
| Lexington, Chillicothe and Gulf Railroad | MP | 1869 | 1870 | Lexington, Lake and Gulf Railroad |
| Lexington, Lake and Gulf Railroad | MP | 1870 | 1879 | Lexington and Southern Railway |
| Lexington and St. Louis Railroad | MP | 1859 | 1877 | St. Louis and Lexington Railroad |
| Lexington and Southern Railway | MP | 1879 | 1880 | Missouri Pacific Railway |
| Linneus Branch of the Burlington and Southwestern Railway | CB&Q | 1871 | 1880 | Chicago, Burlington and Kansas City Railway |
| Little River Valley and Arkansas Railroad | SSW | 1876 | 1881 | Texas and St. Louis Railway |
| Louisiana Bridge Company | GM&O | 1873 | 1873 | Mississippi River Bridge Company |
| Louisiana and Missouri River Railroad | GM&O | 1859 | 1949 | Gulf, Mobile and Ohio Railroad |
| Louisville and Nashville Railroad | L&N, LN | L&N | 1889 | 1983 | Seaboard System Railroad |
| Memphis, Carthage and Northwestern Railroad | SLSF | 1871 | 1877 | Missouri and Western Railway |
| Memphis and St. Louis Railroad | SLSF | 1899 | 1901 | St. Louis and Memphis Railway |
| Middlebrook, Graniteville and Belleview Railroad | 1903 |
| Mill Springs, Current River and Barnesville Railroad | 1884 | 1886 | Missouri Southern Railroad |
| The Milwaukee Road, Inc. | MILW | MILW | 1985 | 1986 | Soo Line Railroad |
| Mineral Belt Railroad | SLSF | 1886 | 1901 | Kansas City, Fort Scott and Memphis Railway |
| Mississippi and Missouri River Air Line Railroad | CB&Q | 1857 | 1871 | Mississippi Valley and Western Railway |
| Mississippi River and Bonne Terre Railway | MP | 1888 | 1945 | Missouri–Illinois Railroad |
| Mississippi River Bridge Company | GM&O | 1873 | 1895 | Louisiana and Missouri River Railroad |
| Mississippi Valley Railroad | CB&Q | 1871 | 1873 | Mississippi Valley and Western Railway |
| Mississippi Valley Railway | 1904 |
| Mississippi Valley and Western Railway | CB&Q | 1871 | 1875 | St. Louis, Keokuk and North Western Railway |
| Missouri and Arkansas Railroad of Missouri | 1880 | 1882 | Eureka Springs Railway |
| Missouri and Arkansas Railway | MAR, MA | 1935 | 1950 | Arkansas and Ozarks Railway |
| Missouri Central Railroad |
| Missouri Central Railway | RI | 1871 | 1881 | Central Railway of Missouri |
| Missouri–Illinois Railroad | MI | MP | 1921 | 1978 | Missouri Pacific Railroad |
| Missouri and Illinois Bridge and Belt Railroad | CB&Q | 1904 | 1966 | Chicago, Burlington and Quincy Railroad |
| Missouri, Iowa and Nebraska Railway | CB&Q | 1870 | 1886 | Keokuk and Western Railroad |
| Missouri, Kansas and Eastern Railway | MKT | 1892 | 1896 | Missouri, Kansas and Texas Railway |
| Missouri, Kansas and Northwestern Railroad | MKT | 1900 | 1902 | Missouri, Kansas and Texas Railway |
| Missouri–Kansas–Texas Railroad | M-K-T, MKT | MKT | 1923 | 1989 | Missouri Pacific Railroad |
| Missouri, Kansas and Texas Railway | MK&T | MKT | 1872 | 1923 | Missouri–Kansas–Texas Railroad |
| Missouri, Kansas and Texas Terminal Company of Kansas City | MKT | 1905 | 1906 | Missouri, Kansas and Texas Railway |
| Missouri, Kansas and Texas Terminal Company of St. Louis | MKT | 1909 | 1925 | Missouri–Kansas–Texas Railroad |
| Missouri and Louisiana Railroad | 1902 | 1914 | Bevier and Southern Railroad |
| Missouri Midland Railway | MKT | 1898 | 1901 | Missouri, Kansas and Texas Railway |
| Missouri and Mississippi Railroad | WAB | 1865 | 1873 | Keokuk and Kansas City Railway |
| Missouri and North Arkansas Railroad | M&NA | 1906 | 1922 | Missouri and North Arkansas Railway |
| Missouri and North Arkansas Railway | M&NA | 1922 | 1935 | Missouri and Arkansas Railway |
| Missouri, Oklahoma and Gulf Railway | MP | 1913 | 1919 | N/A |
| Missouri Pacific Railroad | MP | MP | 1917 | 1997 | Union Pacific Railroad |
| Missouri Pacific Railway | MP | 1876 | 1917 | Missouri Pacific Railroad |
| Missouri River Railroad | MP | 1865 | 1880 | Kansas City, Leavenworth and Atchison Railway |
| Missouri River, Fort Scott and Gulf Railroad | SLSF | 1868 | 1879 | Kansas City, Fort Scott and Gulf Railroad |
| Missouri River Valley Railroad | WAB | 1859 | 1864 | North Missouri Railroad |
| Missouri Southeastern Railway | SLSF | 1891 | 1898 | Cape Girardeau, Bloomfield and Southern Railway |
| Missouri Southern Railroad | MS | 1886 | 1941 | N/A |
| Missouri Valley Railroad | CB&Q | 1867 | 1870 | Kansas City, St. Joseph and Council Bluffs Railroad |
| Missouri Valley Park Railroad | MVP | 2003 | 2010 |
| Missouri and Western Railway | SLSF | 1875 | 1879 | St. Louis and San Francisco Railway |
| Mobile and Ohio Railroad | GM&O | | 1940 | Gulf, Mobile and Ohio Railroad |
| Morley and Morehouse Railroad | SLSF | 1897 | 1902 | St. Louis and Gulf Railway |
| Nevada and Girard Railway | MP | 1882 | 1885 | Nevada and Minden Railway |
| Nevada and Minden Railway | MP | 1885 | 1909 | Missouri Pacific Railway |
| New York Central Railroad | NYC | NYC | 1930 | 1968 | Penn Central Transportation Company |
| New York, Chicago and St. Louis Railroad | NKP | NKP | 1923 | 1964 | Norfolk and Western Railway |
| Nodaway Valley Railroad | CB&Q | 1879 | 1900 | Kansas City, St. Joseph and Council Bluffs Railroad |
| Norfolk and Western Railway | NW | 1964 | 1998 | Norfolk Southern Railway |
| North Missouri Railroad | WAB | 1851 | 1871 | St. Louis, Kansas City and Northern Railway |
| North Missouri Central Railroad |
| Northern Railroad | CB&Q | 1898 | 1898 | Kansas City and Northern Connecting Railroad |
| Ohio and Mississippi Railway | B&O | 1889 | 1893 | Baltimore and Ohio Southwestern Railway |
| Omaha, Kansas City and Eastern Railroad | CB&Q | 1896 | 1902 | Quincy, Omaha and Kansas City Railroad |
| Omaha and St. Louis Railroad | WAB | 1896 | 1901 | Wabash Railroad |
| Omaha and St. Louis Railway | WAB | 1887 | 1896 | Omaha and St. Louis Railroad |
| Oregon Interurban Railway | 1907 |
| Osage Valley and Southern Kansas Railroad | MP | 1857 | 1881 | Boonville, St. Louis and Southern Railway |
| Ozark Southern Railway |
| Ozark Valley Railway |
| Pacific Railroad | MP | 1849 | 1876 | Missouri Pacific Railway |
| Paragould and Buffalo Island Railway | SSW | 1887 | 1893 | Paragould Southeastern Railway |
| Paragould–Memphis Railroad |
| Paragould and Memphis Railway |
| Paragould Southeastern Railway | SSW | 1893 | 1958 | St. Louis Southwestern Railway |
| Pemiscot Railroad | SLSF | 1892 | 1895 | St. Louis, Kennett and Southern Railroad |
| Pemiscot Southern Railroad | SLSF | 1900 | 1902 | St. Louis and Gulf Railway |
| Penn Central Transportation Company | PC | 1968 | 1976 | Consolidated Rail Corporation |
| Pennsylvania Railroad | PRR | PRR | 1921 | 1968 | Penn Central Transportation Company |
| Pierce City and Kansas Railroad | SLSF | 1875 | 1875 | Missouri and Western Railway |
| Pike County Short Line Railroad | 1871 | 1872 | St. Louis and Keokuk Railroad |
| Pilot Knob, Cape Girardeau and Belmont Railroad | SLSF | 1859 | 1869 | Cape Girardeau and State Line Railway |
| Pittsburgh, Cincinnati, Chicago and St. Louis Railroad | PRR | 1917 | 1921 | Pennsylvania Railroad |
| Platte City and Fort Des Moines Railroad | RI | 1864 | 1867 | Leavenworth and Des Moines Railway |
| Platte Country Railroad | CB&Q | 1863 | 1864 | Atchison and St. Joseph Railroad, Weston and Atchison Railroad |
| Platte County Railroad | CB&Q | 1853 | 1863 | Platte Country Railroad |
| Platte County and Fort Des Moines Railroad | RI | 1860 | 1864 | Platte City and Fort Des Moines Railroad |
| Pleasant Hill and De Soto Railroad | SLSF | 1877 | 1885 | Kansas City, Clinton and Springfield Railway |
| Pleasant Hill Division of the Lexington, Chillicothe and Gulf Railroad | MP | 1870 | 1870 | Lexington, Lake and Gulf Railroad |
| Pleasant Hill and Lawrence Branch of the Pacific Railroad | SLSF | | 1870 | St. Louis, Lawrence and Denver Railroad |
| Poplar Bluff and Dan River Railway | 1906 |
| Quincy Bridge Company | CB&Q | 1866 | 1866 | Quincy Railroad Bridge Company |
| Quincy, Missouri and Pacific Railroad | CB&Q | 1869 | 1888 | Quincy, Omaha and Kansas City Railroad |
| Quincy, Omaha and Kansas City Railway | CB&Q | 1887 | 1897 | Quincy, Omaha and Kansas City Railroad |
| Quincy, Omaha and Kansas City Railroad | CB&Q | 1897 | 1939 | Chicago, Burlington and Quincy Railroad |
| Quincy and Palmyra Railroad | CB&Q | 1856 | 1867 | Hannibal and St. Joseph Railroad |
| Quincy Railroad Bridge Company | CB&Q | 1866 | 1903 | Chicago, Burlington and Quincy Railroad |
| Railroad Switching Service of Missouri | RSM | 1989 | 2005 | N/A |
| Rich Hill Railroad | SLSF | 1880 | 1888 | Kansas City, Fort Scott and Springfield Railroad |
| Rock Island – Frisco Terminal Railway | RI/ SLSF | 1906 | 1957 | Chicago, Rock Island and Pacific Railroad, St. Louis – San Francisco Railway |
| Rock Port, Langdon and Northern Railway | 1889 | 1945 | N/A |
| St. Charles Bridge Company | WAB | 1868 | 1878 | St. Louis, Kansas City and Northern Railway |
| St. Clair, Madison and St. Louis Belt Railroad | CB&Q | 1890 | 1904 | Missouri and Illinois Bridge and Belt Railroad |
| St. Francois Valley Railroad | SLSF | 1898 | 1902 | St. Louis and Gulf Railway |
| St. Joseph Belt Railway | SJB | 1908 | | |
| St. Joseph and Central Branch Railway | MP | 1905 | | |
| St. Joseph and Council Bluffs Railroad | CB&Q | 1867 | 1870 | Kansas City, St. Joseph and Council Bluffs Railroad |
| St. Joseph and Des Moines Railroad | CB&Q | 1877 | 1901 | Chicago, Burlington and Quincy Railroad |
| St. Joseph and Grand Island Railway | SJGI | UP | 1898 | 1936 | Union Pacific Railroad |
| St. Joseph and Iowa Railroad | RI | 1857 | 1888 | Chicago, Rock Island and Pacific Railway |
| St. Joseph and Nebraska Railroad | CB&Q | 1882 | 1901 | Chicago, Burlington and Quincy Railroad |
| St. Joseph and St. Louis Railroad | ATSF | 1874 | 1888 | St. Joseph, St. Louis and Santa Fe Railway |
| St. Joseph, St. Louis and Santa Fe Railway | ATSF | 1888 | 1900 | Atchison, Topeka and Santa Fe Railway |
| St. Joseph and Santa Fe Railroad | ATSF | 1887 | 1888 | St. Joseph, St. Louis and Santa Fe Railway |
| St. Joseph Terminal Company | ATSF/ UP | 1886 | 1887 | St. Joseph Terminal Railroad |
| St. Joseph Terminal Railroad | SJT | ATSF/ UP | 1887 | Still exists as a joint subsidiary of the BNSF Railway and Union Pacific Railroad |
| St. Joseph Union Depot Company | ATSF/ CB&Q/ CGW/ MP/ RI/ UP | 1880 | 1962 | N/A |
| St. Louis, Arkansas and Texas Railway | SSW | 1886 | 1891 | St. Louis Southwestern Railway |
| St. Louis, Arkansas and Texas Railway | SLSF | 1880 | 1882 | St. Louis and San Francisco Railway |
| St. Louis, Arkansas and Texas Terminal Railway | SSW | 1888 | 1888 | St. Louis, Arkansas and Texas Railway |
| St. Louis Belt and Terminal Railway | 1902 | | Terminal Railroad Association of St. Louis |
| St. Louis Bridge Company | 1878 | | Terminal Railroad Association of St. Louis |
| St. Louis, Cape Girardeau and Fort Smith Railway | SLSF | 1891 | 1899 | Southern Missouri and Arkansas Railroad |
| St. Louis, Cape Girardeau and Southern Railroad | 1900 | 1902 | Cape Girardeau and Chester Railroad |
| St. Louis, Caruthersville and Memphis Railroad | SLSF | 1897 | 1901 | St. Louis and Memphis Railway |
| St. Louis and Central Missouri Railway | RI | 1883 | 1886 | St. Louis, Kansas City and Colorado Railroad |
| St. Louis, Chillicothe and Omaha Railroad | WAB | 1868 | 1869 | Chillicothe and Omaha Railroad |
| St. Louis, Council Bluffs and Omaha Railroad | WAB | 1870 | 1924 | Wabash Railway |
| St. Louis and Fort Scott Railroad | RI | 1870 | 1871 | Missouri Central Railway |
| St. Louis and Gulf Railway | SLSF | 1902 | 1904 | St. Louis, Memphis and Southeastern Railroad |
| St. Louis and Hannibal Railroad | SL&H, SLH | 1917 | 1944 | N/A |
| St. Louis and Hannibal Railway | 1885 | 1917 | St. Louis and Hannibal Railroad |
| St. Louis, Hannibal and Kansas City Railway | 1891 | 1893 | St. Louis, Hannibal and Keokuk Railroad |
| St. Louis, Hannibal and Keokuk Railroad | 1872 | 1885 | St. Louis and Hannibal Railway |
| St. Louis and Illinois Bridge Company | 1864 | 1868 | Illinois and St. Louis Bridge Company |
| St. Louis and Iron Mountain Railroad | MP | 1851 | 1874 | St. Louis, Iron Mountain and Southern Railway |
| St. Louis, Iron Mountain and Southern Railway | MP | 1874 | 1917 | Missouri Pacific Railway |
| St. Louis, Kansas and Arizona Railway | MP | 1879 | 1880 | Missouri Pacific Railway |
| St. Louis and Kansas City Railway | MKT | 1895 | 1895 | Missouri, Kansas and Texas Railway |
| St. Louis, Kansas City and Colorado Railroad | RI | 1884 | 1905 | Kansas City Rock Island Railway |
| St. Louis, Kansas City and Northern Railway | WAB | 1872 | 1879 | Wabash, St. Louis and Pacific Railway |
| St. Louis, Kennett and Southeastern Railroad | SLSF | 1906 | 1950 | St. Louis – San Francisco Railway |
| St. Louis, Kennett and Southern Railroad | SLSF | 1890 | 1902 | St. Louis and Gulf Railway |
| St. Louis and Keokuk Railroad | 1857 | 1872 | St. Louis, Hannibal and Keokuk Railroad |
| St. Louis, Keokuk and Northwestern Railroad | CB&Q | 1887 | 1901 | Chicago, Burlington and Quincy Railroad |
| St. Louis, Keokuk and North Western Railway | CB&Q | 1875 | 1887 | St. Louis, Keokuk and Northwestern Railroad |
| St. Louis, Lawrence and Denver Railroad | SLSF | 1870 | 1874 | St. Louis, Lawrence and Western Railroad |
| St. Louis, Lawrence and Western Railroad | SLSF | 1874 | 1877 | Pleasant Hill and De Soto Railroad |
| St. Louis and Lexington Railroad | MP | 1877 | 1880 | Missouri Pacific Railway |
| St. Louis and Memphis Railroad | SLSF | 1898 | 1901 | St. Louis and Memphis Railway |
| St. Louis and Memphis Railway | SLSF | 1901 | 1902 | St. Louis, Memphis and Southeastern Railroad |
| St. Louis, Memphis and Southeastern Railroad | SLSF | 1902 | 1907 | St. Louis and San Francisco Railroad |
| St. Louis Merchants Bridge Company | 1886 | 1920 | St. Louis Merchants Bridge Terminal Railway |
| St. Louis Merchants Bridge Terminal Railway | SLMB | 1887 | | Terminal Railroad Association of St. Louis |
| St. Louis and Missouri Southern Railway | 1910 |
| St. Louis, Morehouse and Southern Railroad | SLSF | 1899 | 1904 | St. Louis and Gulf Railway |
| St. Louis and North Arkansas Railway | 1899 | 1906 | Missouri and North Arkansas Railroad |
| St. Louis, Oak Hill and Carondelet Railway | MP | 1886 | 1910 | Missouri Pacific Railway |
| St. Louis Railway and Dock Company |
| St. Louis and St. Joseph Railroad | ATSF | 1868 | 1874 | St. Joseph and St. Louis Railroad |
| St. Louis, Salem and Arkansas Railway | SLSF | 1887 | 1897 | St. Louis and San Francisco Railroad |
| St. Louis, Salem and Little Rock Railroad | SLSF | 1871 | 1887 | St. Louis, Salem and Arkansas Railway |
| St. Louis and San Francisco Railroad | SLSF | 1896 | 1916 | St. Louis – San Francisco Railway |
| St. Louis and San Francisco Railway | SLSF | 1876 | 1896 | St. Louis and San Francisco Railroad |
| St. Louis – San Francisco Railway | SLSF | SLSF | 1916 | 1980 | Burlington Northern Inc. |
| St. Louis and Santa Fe Railroad, Missouri Division | MKT | 1869 | 1872 | Missouri, Kansas and Texas Railway |
| St. Louis Southwestern Railway | SSW | SSW | 1891 | 1997 | Union Pacific Railroad |
| St. Louis Terminal Railway | 1892 | | Terminal Railroad Association of St. Louis |
| St. Louis Transfer Railway | 1884 | | Terminal Railroad Association of St. Louis |
| St. Louis Tunnel Railroad | 1872 | 1878 | Tunnel Railroad of St. Louis |
| St. Paul and Kansas City Short Line Railroad | RI | 1911 | 1948 | Chicago, Rock Island and Pacific Railroad |
| Salem, Winona and Southern Railroad | 1908 | 1928 | N/A |
| Saline Valley Railroad | 1904 | 1913 | Cape Girardeau Northern Railway |
| Salisbury and Glasgow Railroad | WAB | 1877 | 1877 | St. Louis, Kansas City and Northern Railway |
| Seaboard System Railroad | SBD | 1983 | 1986 | CSX Transportation |
| Sedalia, Warsaw and Southern Railway | MP | 1879 | 1891 | Sedalia, Warsaw and South Western Railway |
| Sedalia, Warsaw and South Western Railway | MP | 1891 | 1910 | Missouri Pacific Railway |
| Shelby County Railway | 1906 | 1938 | N/A |
| Shelby Northwestern Railway | 1911 | 1938 | N/A |
| Short Creek and Joplin Railroad | SLSF | 1879 | 1888 | Kansas City, Fort Scott and Springfield Railroad |
| Sibley Bridge Company | ATSF | 1887 | 1900 | Atchison, Topeka and Santa Fe Railway |
| Sligo and Eastern Railroad | SL&E | 1902 | 1929 | N/A |
| Sligo Furnace Railroad | SLSF | 1880 | 1881 | St. Louis, Salem and Little Rock Railroad |
| Soo Line Railroad | SOO | 1986 | 1997 | I&M Rail Link |
| South Pacific Railroad | SLSF | 1868 | 1870 | Atlantic and Pacific Railroad |
| Southern Railway | SOU | SOU | 1902 | 1990 | Norfolk Southern Railway |
| Southern Missouri Railway | MP | 1900 | 1903 | Illinois Southern Railway |
| Southern Missouri and Arkansas Railroad | SLSF | 1899 | 1902 | St. Louis, Memphis and Southeastern Railroad |
| Southwest Pacific Railroad | SLSF | 1866 | 1868 | South Pacific Railroad |
| Springfield Connecting Railway | SLSF | 1886 | 1926 | St. Louis – San Francisco Railway |
| Springfield and Northern Railway | SLSF | 1884 | 1885 | St. Louis and San Francisco Railway |
| Springfield and Southern Railway | SLSF | 1882 | 1885 | St. Louis and San Francisco Railway |
| Springfield Southwestern Railway | MP | 1903 | 1909 | St. Louis, Iron Mountain and Southern Railway |
| Springfield and Western Missouri Railroad | SLSF | 1877 | 1888 | Kansas City, Springfield and Memphis Railroad |
| Springfield Western and Southern Railroad of Missouri | SLSF | 1875 | 1877 | Springfield and Western Missouri Railroad |
| Tarkio Valley Railroad | CB&Q | 1880 | 1900 | Kansas City, St. Joseph and Council Bluffs Railroad |
| Tebo and Neosho Railroad | MKT | 1860 | 1872 | Missouri, Kansas and Texas Railway |
| Terminal Railroad of St. Louis | 1880 | 1889 | Terminal Railroad Association of St. Louis |
| Terre Haute and Indianapolis Railroad | PRR | 1902 | 1905 | Vandalia Railroad |
| Texas and St. Louis Railway | SSW | 1881 | 1886 | St. Louis, Arkansas and Texas Railway |
| Toledo, St. Louis and Western Railroad | NKP | | 1923 | New York, Chicago and St. Louis Railroad |
| Tunnel Railroad of St. Louis | 1878 | 1988 | City of St. Louis (for MetroLink) | Owned by Terminal Railroad Association of St. Louis |
| Union Belt Line | 1882 | 1882 | Kansas City Belt Railway |
| Union Depot Company | 1875 | 1910 | Kansas City Terminal Railway |
| Union Depot Company of St. Louis | 1874 | 1889 | Terminal Railroad Association of St. Louis |
| Union Depot Bridge and Terminal Railroad |
| Union Pacific Railway | UP | 1880 | 1898 | Union Pacific Railroad |
| Union Pacific Railway, Eastern Division | UP | 1863 | 1869 | Kansas Pacific Railway |
| Union Railway and Transit Company of St. Louis | 1874 | 1889 | Terminal Railroad Association of St. Louis |
| Union Terminal Railway | UT | 1901 | | |
| Union Transit Company | 1880 | 1884 | Kansas City Belt Railway |
| Vandalia Railroad | PRR | 1905 | 1917 | Pittsburgh, Cincinnati, Chicago and St. Louis Railroad |
| Wabash Railroad | WAB | WAB | 1942 | 1991 | Norfolk and Western Railway |
| Wabash Railroad | WAB | 1889 | 1915 | Wabash Railway |
| Wabash Railway | WAB | 1915 | 1942 | Wabash Railroad |
| Wabash and Grand River Railway | WGRY | 1990 | 1993 | Chillicothe–Brunswick Rail Maintenance Authority |
| Wabash – Hannibal Bridge Company | WAB | 1937 | 1943 | Wabash Railroad |
| Wabash, St. Louis and Pacific Railway | WAB | 1879 | 1886 | Omaha and St. Louis Railway, Wabash Western Railway |
| Wabash Western Railway | WAB | 1887 | 1889 | Wabash Railroad |
| Warrensburg and Pertle Springs Railroad |
| Western Cable Railway |
| Weston and Atchison Railroad | CB&Q | 1859 | 1867 | Missouri Valley Railroad |
| Williamsville, Greenville and St. Louis Railway | 1894 |
| Wyandotte, Kansas City and Northwestern Railway | MP | 1872 | 1878 | Kansas City and Eastern Railway |
1. ^This is one or more of the Class I railroads that the railroad became part of, if any.