“Neurotrophic factor receptor”的意思、由来-开放百科全书

词条

Neurotrophic factor receptor

释义

TrkA, B, and C receptors
LNGFR receptor
References
External links

Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors).

Two classes of neurotrophic factor receptors are the p75 and the "Trk" families of Tyrosine kinases receptors.

p75 is a low affinity neurotrophin receptor, to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase "x" only applies to this receptor.^[1]
The Trk family include TrkA, TrkB, and TrkC, and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins.
NGF binds to TrkA, BDNF and NT-4 bind to TrkB and NT-3 binds to TrkC. In addition NT-3 also binds to and activates TrkA and TrkB but it does so less efficiently.
Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis.

TrkA, B, and C receptors

TrkA mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling.

There are other related Trk receptors (TrkB and TrkC), and there are other neurotrophic factors structurally related to NGF (BDNF, NT-3, and NT-4)

TrkA mediates the effects of NGF
TrkB binds and is activated by BDNF, NT-4, and NT-3
TrkC binds and is activated only by NT-3

LNGFR receptor

The other NGF receptor, the LNGFR, (for Low affinity nerve growth factor receptor, commonly known as "p75", plays a less clear role.

LNGFR binds and serves as a "sink" for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity - since they have a higher "microconcentration" of the neurotrophin.

However, although NGF has been classically described as promoting neuron survival and differentiation, research performed in the early 2000s suggest that NGF with its prodomain attached (proNGF) can elicit apoptosis of cells that are positive for the LNGFR and negative for TrkA.^[2]

Secreted proNGF has been demonstrated in a variety of neuronal and non-neuronal cell populations. It has been proposed that secreted proNGF can elicit neuron death in a variety of neurodegenerative conditions, including Alzheimer's disease, following the observation of an increase of proNGF in the nucleus basalis of postmortem Alzheimer's brains.

References

1. ^{{MeshName|Nerve+Growth+Factor+Receptor+p75}}
2. ^{{cite journal |author=Ibáñez C |title=Jekyll-Hyde neurotrophins: the story of proNGF |journal=Trends Neurosci |volume=25 |issue=6 |pages=284–6 |year=2002 |pmid=12086739 |doi=10.1016/S0166-2236(02)02169-0}}

External links

{{MeshName|Nerve+Growth+Factor+Receptors}}

2 : Receptors|Single-pass transmembrane proteins

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。