| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.[1] Function Expression of interleukin-3 (IL3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[1][2] References 1. ^1 {{cite web | title = Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4783| accessdate = }}
2. ^{{cite journal | vauthors = Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD | title = Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter | journal = Molecular and Cellular Biology | volume = 15 | issue = 11 | pages = 6055–63 | date = November 1995 | pmid = 7565758 | pmc = 230857 | doi = }}
Further reading {{refbegin|35em}}- {{cite journal | vauthors = Cowell IG, Skinner A, Hurst HC | title = Transcriptional repression by a novel member of the bZIP family of transcription factors | journal = Molecular and Cellular Biology | volume = 12 | issue = 7 | pages = 3070–7 | date = July 1992 | pmid = 1620116 | pmc = 364521 | doi = }}
- {{cite journal | vauthors = Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD | title = Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter | journal = Molecular and Cellular Biology | volume = 15 | issue = 11 | pages = 6055–63 | date = November 1995 | pmid = 7565758 | pmc = 230857 | doi = }}
- {{cite journal | vauthors = Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K | title = The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression | journal = Gene | volume = 146 | issue = 2 | pages = 199–207 | date = September 1994 | pmid = 8076819 | doi = 10.1016/0378-1119(94)90293-3 }}
- {{cite journal | vauthors = Cowell IG, Hurst HC | title = Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1 | journal = Nucleic Acids Research | volume = 24 | issue = 18 | pages = 3607–13 | date = September 1996 | pmid = 8836190 | pmc = 146135 | doi = 10.1093/nar/24.18.3607 }}
- {{cite journal | vauthors = Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT | title = Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 6 | pages = 2609–14 | date = March 1997 | pmid = 9122243 | pmc = 20136 | doi = 10.1073/pnas.94.6.2609 }}
- {{cite journal | vauthors = Hulme DJ, Blair IP, Dawkins JL, Nicholson GA | title = Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis | journal = Human Genetics | volume = 106 | issue = 6 | pages = 594–6 | date = June 2000 | pmid = 10942106 | doi = 10.1007/s004390050030 }}
- {{cite journal | vauthors = Ozkurt IC, Tetradis S | title = Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26803–9 | date = July 2003 | pmid = 12743120 | doi = 10.1074/jbc.M212652200 }}
- {{cite journal | vauthors = Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD | title = Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 2 | pages = 491–9 | date = June 2006 | pmid = 16630563 | pmc = 2763529 | doi = 10.1016/j.bbrc.2006.03.169 }}
{{refend}}{{NLM content}}{{Transcription factors|g1}}{{gene-9-stub}} 1 : Transcription factors |