“N-formylmethionylaminoacyl-tRNA deformylase”的意思、由来-开放百科全书

词条

N-formylmethionylaminoacyl-tRNA deformylase

释义

Structural studies
References

{{enzyme
| Name = N-formylmethionylaminoacyl-tRNA deformylase
| EC_number = 3.5.1.27
| CAS_number = 37289-08-0
| IUBMB_EC_number = 3/5/1/27
| GO_code = 0047410
| image =
| width =
| caption =
}}

In enzymology, a N-formylmethionylaminoacyl-tRNA deformylase ({{EC number|3.5.1.27}}) is an enzyme that catalyzes the chemical reaction

N-formyl-L-methionylaminoacyl-tRNA + H₂O formate + L-methionylaminoacyl-tRNA

Thus, the two substrates of this enzyme are N-formyl-L-methionylaminoacyl-tRNA and H₂O, whereas its two products are formate and L-methionylaminoacyl-tRNA.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-formyl-L-methionylaminoacyl-tRNA amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1BSJ}}, {{PDB link|1BSK}}, and {{PDB link|1LMH}}.

References

{{cite journal | vauthors = Livingston DM, Leder P | date = 1969 | title = Deformylation and protein biosynthesis | journal = Biochemistry | volume = 8 | pages = 435–43 | pmid = 4887858 | doi = 10.1021/bi00829a059 | issue = 1 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.1|Enzymes of known structure

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