“Nicotinate-nucleotide adenylyltransferase”的意思、由来-开放百科全书

词条

Nicotinate-nucleotide adenylyltransferase

释义

Structural studies
References

{{enzyme
| Name = nicotinate-nucleotide adenylyltransferase
| EC_number = 2.7.7.18
| CAS_number = 9026-98-6
| IUBMB_EC_number = 2/7/7/18
| GO_code = 0004515
| image =
| width =
| caption =
}}

In enzymology, a nicotinate-nucleotide adenylyltransferase ({{EC number|2.7.7.18}}) is an enzyme that catalyzes the chemical reaction

ATP + nicotinate ribonucleotide diphosphate + deamido-NAD⁺

Thus, the two substrates of this enzyme are ATP and nicotinate ribonucleotide, whereas its two products are diphosphate and deamido-NAD+.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:nicotinate-ribonucleotide adenylyltransferase. Other names in common use include deamido-NAD+ pyrophosphorylase, nicotinate mononucleotide adenylyltransferase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, NaMN-ATase, and nicotinic acid mononucleotide adenylyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1K4K}}, {{PDB link|1K4M}}, {{PDB link|1KAM}}, {{PDB link|1KAQ}}, {{PDB link|1YUL}}, {{PDB link|1YUM}}, {{PDB link|1YUN}}, {{PDB link|2H29}}, and {{PDB link|2H2A}}.

References

{{cite journal | vauthors = Imsande J | title = Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli | journal = The Journal of Biological Chemistry | volume = 236 | pages = 1494–7 | date = May 1961 | pmid = 13717628 }}

2 : EC 2.7.7|Enzymes of known structure

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