| 词条 | NLRC5 |
| 释义 |
Recently, NLRC5 has been suggested to play a positive role in the regulation of Major Histocompatibility Class I (MHCI) molecule expression.[4] This aspect of NLRC5 function was further investigated with the help of Nlrc5-deficient mice, which showed reduced MHCI expression in lymphocytes (particularly T, NK and NKT lymphocytes).[5] In lymphocytes, NLRC5 localizes to the nucleus and drives MHCI gene expression by occupying H-2D and H-2K gene promoters.[5] In humans, the NLRC5 protein is encoded by the NLRC5 gene.[6] It has also been called NOD27, NOD4, and CLR16.1. References1. ^{{cite journal |vauthors=Neerincx A, Lautz K, Menning M, etal |title=A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses |journal=J Biol Chem |volume= 285|issue= 34|pages= 26223–32|date=June 2010 |pmid=20538593 |pmc=2924034 |doi=10.1074/jbc.M110.109736 |url=}} {{NOD-like receptors}}{{protein-stub}}2. ^{{cite journal |vauthors=Cui J, Zhu L, Xia X, etal |title=NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity |journal=Cell |volume=141 |issue=3 |pages=483–96 |date=April 2010 |pmid=20434986 |doi=10.1016/j.cell.2010.03.040 |url= |pmc=3150216}} 3. ^{{cite journal |vauthors=Kuenzel S, Till A, Winkler M, etal |title=The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses |journal=J. Immunol. |volume=184 |issue=4 |pages=1990–2000 |date=February 2010 |pmid=20061403 |doi=10.4049/jimmunol.0900557 |url=}} 4. ^{{cite journal|last=Meissner |first=TB |last2=Li |first2=A |last3=Biswas |first3=A |last4=Lee |first4=K |last5=Liu |first5=Y |last6=Bayir |first6=E |last7=Iliopoulos |first7=D |last8=van den Elsen |first8=PJ |last9=Kobayashi |first9=KS|title=NLR family member NLRC5 is a transcriptional regulator of MHC class I genes|journal=Proc. Natl. Acad. Sci.|date=August 2010|volume=107|issue=31|pages=13794–13799|doi=10.1073/pnas.1008684107|pmid=20639463 |pmc=2922274}} 5. ^1 {{cite journal|last=Staehli |first=F |last2=Ludigs |first2=K |last3=Heinz |first3=LX |last4=Seguín-Estévez |first4=Q |last5=Ferrero |first5=I |last6=Braun |first6=M |last7=Schroder |first7=K |last8=Rebsamen |first8=M |last9=Tardivel |first9=A |last10=Mattmann |first10=C |last11=MacDonald |first11= HR |last12=Romero |first12=P |last13=Reith |first13=W |last14=Guarda |first14=G |last15=Tschopp |first15=J|title=NLRC5 Deficiency Selectively Impairs MHC Class I-Dependent Lymphocyte Killing by Cytotoxic T Cells|journal=J Immunol|date=April 2012|volume=188|issue=8|doi=10.4049/jimmunol.1102671|pmid=22412192|url=http://www.jimmunol.org/content/early/2012/03/12/jimmunol.1102671.abstract|accessdate=23 March 2012|pages=3820–8}} 6. ^{{cite journal |vauthors=Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G | title = Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product | journal = Biochem. Biophys. Res. Commun. | volume = 302 | issue = 3 | pages = 575–80 |date=March 2003 | pmid = 12615073 | doi = 10.1016/S0006-291X(03)00221-3| url = }} 2 : LRR proteins|NOD-like receptors |
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