“NOL1”的意思、由来-开放百科全书

The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.^[3]

Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.^[4] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.^[5]

Interactions

References

1. ^{{cite journal | vauthors = Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P | title = Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids | journal = Genomics | volume = 21 | issue = 1 | pages = 296–7 | date = October 1994 | pmid = 8088812 | pmc = | doi = 10.1006/geno.1994.1267 }}
2. ^{{cite web | title = Entrez Gene: NOL1 nucleolar protein 1, 120kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4839| accessdate = }}
3. ^{{cite journal | vauthors = Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H | title = Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase | journal = Cancer Res. | volume = 48 | issue = 5 | pages = 1244–51 | date = 1 March 1988 | pmid = 3422591 | url = http://cancerres.aacrjournals.org/cgi/content/abstract/48/5/1244 }}
4. ^{{cite journal | vauthors = Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H | title = Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct | journal = Cancer Res. | volume = 52 | issue = 2 | pages = 428–36 | date = January 1992 | pmid = 1728415 | doi = | url = http://cancerres.aacrjournals.org/cgi/content/abstract/52/2/428 }}
5. ^{{cite journal | vauthors = Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW | title = Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts | journal = J. Cell. Physiol. | volume = 154 | issue = 1 | pages = 16–27 | date = January 1993 | pmid = 8419402 | doi = 10.1002/jcp.1041540104 }}
6. ^{{cite journal | vauthors = Ren Y, Busch RK, Perlaky L, Busch H | title = The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120 | journal = Eur. J. Biochem. | volume = 253 | issue = 3 | pages = 734–42 | date = May 1998 | pmid = 9654073 | doi = 10.1046/j.1432-1327.1998.2530734.x }}

Further reading

{{cite journal | vauthors = Busch H | title = The final common pathway of cancer | journal = Cancer Res. | volume = 50 | issue = 16 | pages = 4830–8 | year = 1990 | pmid = 2199030 | doi = }}

{{cite journal | vauthors = Valdez BC, Perlaky L, Saijo Y, Henning D, Zhu C, Busch RK, Zhang WW, Busch H | title = A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation | journal = Cancer Res. | volume = 52 | issue = 20 | pages = 5681–6 | year = 1992 | pmid = 1394192 | doi = }}

{{cite journal | vauthors = Larson RG, Henning D, Haidar MA, Jhiang S, Lin WL, Zhang WW, Busch H | title = Genomic structure of the human proliferating cell nucleolar protein P120 | journal = Cancer Commun. | volume = 2 | issue = 2 | pages = 63–71 | year = 1990 | pmid = 2372471 | doi = 10.3727/095535490820874704}}

{{cite journal | vauthors = Fonagy A, Henning D, Jhiang S, Haidar M, Busch RK, Larson R, Valdez B, Busch H | title = Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120 | journal = Cancer Commun. | volume = 1 | issue = 4 | pages = 243–51 | year = 1989 | pmid = 2576976 | doi = }}

{{cite journal | vauthors = Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H | title = Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase | journal = Cancer Res. | volume = 48 | issue = 5 | pages = 1244–51 | year = 1988 | pmid = 3422591 | doi = }}

{{cite journal | vauthors = Valdez BC, Perlaky L, Henning D, Saijo Y, Chan PK, Busch H | title = Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23 | journal = J. Biol. Chem. | volume = 269 | issue = 38 | pages = 23776–83 | year = 1994 | pmid = 8089149 | doi = }}

{{cite journal | vauthors = Jallal B, Mossie K, Vasiloudis G, Knyazev P, Zachwieja J, Clairvoyant F, Schilling J, Ullrich A | title = The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 12158–63 | year = 1997 | pmid = 9115287 | doi = 10.1074/jbc.272.18.12158 }}

{{cite journal | vauthors = Ren Y, Busch RK, Perlaky L, Busch H | title = The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120 | journal = Eur. J. Biochem. | volume = 253 | issue = 3 | pages = 734–42 | year = 1998 | pmid = 9654073 | doi = 10.1046/j.1432-1327.1998.2530734.x }}

{{cite journal | vauthors = Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG | title = Nucleophosmin regulates the stability and transcriptional activity of p53 | journal = Nat. Cell Biol. | volume = 4 | issue = 7 | pages = 529–33 | year = 2002 | pmid = 12080348 | doi = 10.1038/ncb814 }}

{{cite journal | vauthors = Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B | title = The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn) | journal = Oncogene | volume = 21 | issue = 46 | pages = 7067–76 | year = 2002 | pmid = 12370829 | doi = 10.1038/sj.onc.1205858 }}

{{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4100–9 | year = 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}

{{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}

{{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

{{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}

{{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}

{{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}