| 词条 | Nooglutyl |
| 释义 |
| ImageFile = Nooglutyl.svg | ImageSize = 200px | IUPACName = N-[(5-Hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid | OtherNames = Nooglutil |Section1={{Chembox Identifiers | CASNo = 112193-35-8 | PubChem = 147523 | ChemSpiderID = 130090 | SMILES = O=C(c1cncc(O)c1)N[C@H](C(=O)O)CCC(=O)O | InChI = 1/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1 | InChIKey = XFZGYOJFPGPYCS-QMMMGPOBBD | StdInChI = 1S/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1 | StdInChIKey = XFZGYOJFPGPYCS-QMMMGPOBSA-N |Section2={{Chembox Properties | C=11 | H=12 | N=2 | O=6 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Nooglutyl is a nootropic agent that was studied at the Research Institute of Pharmacology, Russian Academy of Medical Sciences as a potential treatment for amnesia.[1] In animal models, it has a variety of central nervous system effects.[2][3][4][5] References1. ^{{Cite journal | title = Nooglutil, Russian Academy of Medical Science | author = Flekhter, Oxana B. | year = 2000 | journal = Current Opinion in Central & Peripheral Nervous System Investigational Drugs | volume = 2 | issue = 4 | pages = 491–497}} {{Nootropics}}{{Ionotropic glutamate receptor modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal|author1=V. V. Yasnetsov |author2=V. A. Pravdivtsev |author3=V. M. Popov |author4=T. A. Voronina |author5=N. M. Kiseleva |author6=S. B. Kozlov | title = Antimotion Effect of Nooglutyl and Its Neuronal Mechanism| journal = Bulletin of Experimental Biology and Medicine| volume = 119| issue = 5| pages = 515–516| date=May 1995| pmid = 7579248| url = http://www.springerlink.com/content/d63188562u612346/| accessdate = 2011-02-08| doi = 10.1007/BF02543440}} 3. ^{{Cite journal | pmid = 12802448 | year = 2002 | last1 = Voronina | first1 = TA | last2 = Borlikova | first2 = GG | last3 = Garibova | first3 = TL | last4 = Proskuryakova | first4 = TV | last5 = Petrichenko | first5 = OB | last6 = Burd | first6 = SG | last7 = Avakyan | first7 = GN | title = Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum | volume = 134 | issue = 5 | pages = 448–50 | journal = Bulletin of experimental biology and medicine}} 4. ^{{Cite journal | pmid = 12924225 | year = 2003 | last1 = Garibova | first1 = TL | last2 = Galaeva | first2 = IP | last3 = Voronina | first3 = TA | last4 = Kraĭneva | first4 = VA | last5 = Kapitsa | first5 = IG | last6 = Kirichenko | first6 = SV | last7 = Makarenko | first7 = AN | last8 = Mirzoian | first8 = GR | last9 = Kuznetsova | first9 = EA | title = Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke) | volume = 66 | issue = 3 | pages = 13–6 | journal = Eksperimental'naia i klinicheskaia farmakologiia }} 5. ^{{Cite journal | pmid = 15079898 | year = 2004 | last1 = Povarova | first1 = OV | last2 = Garibova | first2 = TL | last3 = Kalenikova | first3 = EI | last4 = Galaeva | first4 = IP | last5 = Kraĭneva | first5 = VA | last6 = Medvedev | first6 = OS | last7 = Voronina | first7 = TA | title = Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion | volume = 67 | issue = 1 | pages = 3–6 | journal = Eksperimental'naia i klinicheskaia farmakologiia}} 4 : AMPA receptor positive allosteric modulators|Nootropics|Nicotinamides|Dicarboxylic acids |
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