词条 | NOS1AP |
释义 |
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.[3] NOS1AP polymorphisms has been associated with the QT interval length.[4] InteractionsNOS1AP has been shown to interact with:
References1. ^{{cite journal | vauthors = Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O | title = Characterization of cDNA clones in size-fractionated cDNA libraries from human brain | journal = DNA Res. | volume = 4 | issue = 5 | pages = 345–9 | date = February 1998 | pmid = 9455484 | pmc = | doi = 10.1093/dnares/4.5.345 }} 2. ^1 {{cite journal | vauthors = Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH | title = CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95 | journal = Neuron | volume = 20 | issue = 1 | pages = 115–24 | date = Mar 1998 | pmid = 9459447 | pmc = | doi = 10.1016/S0896-6273(00)80439-0 }} 3. ^1 {{cite web | title = Entrez Gene: NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9722| accessdate = }} 4. ^{{cite journal | vauthors = Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marbán E, O'Donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A | title = A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization | journal = Nat. Genet. | volume = 38 | issue = 6 | pages = 644–51 | year = 2006 | pmid = 16648850 | doi = 10.1038/ng1790 }} 5. ^1 {{cite journal | vauthors = Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J | title = Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25616–24 | date = August 2000 | pmid = 10827173 | doi = 10.1074/jbc.M000955200 }} 6. ^{{cite journal | vauthors = Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH | title = Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON | journal = Neuron | volume = 28 | issue = 1 | pages = 183–93 | date = October 2000 | pmid = 11086993 | doi = 10.1016/S0896-6273(00)00095-7 }} 7. ^{{cite journal | vauthors = Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH | title = Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 3199–204 | date = March 2002 | pmid = 11867766 | pmc = 122496 | doi = 10.1073/pnas.261705799 }} Further reading{{refbegin | 2}}
1 : Biology of bipolar disorder |
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