| 释义 |
- References
- Further reading
{{Infobox_gene}}RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.[2]
}}References1. ^{{cite journal | vauthors = Buckanovich RJ, Yang YY, Darnell RB | title = The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies | journal = J Neurosci | volume = 16 | issue = 3 | pages = 1114–22 |date=Feb 1996 | pmid = 8558240 | pmc = | doi = }}
2. ^1 {{cite web | title = Entrez Gene: NOVA1 neuro-oncological ventral antigen 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4857| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Buckanovich RJ, Posner JB, Darnell RB |title=Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system |journal=Neuron |volume=11 |issue= 4 |pages= 657–72 |year= 1993 |pmid= 8398153 |doi=10.1016/0896-6273(93)90077-5 }}
- {{cite journal | vauthors=Buckanovich RJ, Darnell RB |title=The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3194–201 |year= 1997 |pmid= 9154818 |doi= | pmc=232172 }}
- {{cite journal |vauthors=Lewis HA, Chen H, Edo C, etal |title=Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains |journal=Structure |volume=7 |issue= 2 |pages= 191–203 |year= 1999 |pmid= 10368286 |doi=10.1016/S0969-2126(99)80025-2 }}
- {{cite journal |vauthors=Jensen KB, Dredge BK, Stefani G, etal |title=Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability |journal=Neuron |volume=25 |issue= 2 |pages= 359–71 |year= 2000 |pmid= 10719891 |doi=10.1016/S0896-6273(00)80900-9 }}
- {{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal | vauthors=Dredge BK, Darnell RB |title=Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer |journal=Mol. Cell. Biol. |volume=23 |issue= 13 |pages= 4687–700 |year= 2003 |pmid= 12808107 |doi=10.1128/MCB.23.13.4687-4700.2003 | pmc=164843 }}
- {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ule J, Ule A, Spencer J, etal |title=Nova regulates brain-specific splicing to shape the synapse |journal=Nat. Genet. |volume=37 |issue= 8 |pages= 844–52 |year= 2005 |pmid= 16041372 |doi= 10.1038/ng1610 }}
- {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
{{refend}}{{PDB Gallery|geneid=4857}}{{gene-14-stub}} |