| 词条 | NS-2664 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 424949355 | IUPAC_name = 5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole | image = NS-2664.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 9840300 | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 8016018 | C=20 | H=14 | N=4 | O=1 | molecular_weight = 326.351 g/mol | smiles = c5occc5-c(cc1nc4)ccc1n4-c2cc(ccc2)-n3cncc3 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C20H14N4O/c1-2-17(23-8-7-21-13-23)11-18(3-1)24-14-22-19-10-15(4-5-20(19)24)16-6-9-25-12-16/h1-14H | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = QMKRPSVBKKEAKS-UHFFFAOYSA-N }}NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.[1] References1. ^Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. {{PMID|16352707}} {{Anxiolytics}}{{GABAAR PAMs}}{{nervous-system-drug-stub}} 5 : Anxiolytics|Furans|Benzimidazoles|Imidazoles|GABAA receptor positive allosteric modulators |
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