“NUB1”的意思、由来-开放百科全书

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM]^[3]

References

1. ^{{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | pmc = | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
2. ^{{cite journal | vauthors = Kito K, Yeh ET, Kamitani T | title = NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 20603–9 | date = Jun 2001 | pmid = 11259415 | pmc = | doi = 10.1074/jbc.M100920200 }}
3. ^¹{{cite web | title = Entrez Gene: NUB1 negative regulator of ubiquitin-like proteins 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51667| accessdate = }}
4. ^¹{{cite journal | vauthors = Hipp MS, Raasi S, Groettrup M, Schmidtke G | title = NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 16503–10 | date = Apr 2004 | pmid = 14757770 | doi = 10.1074/jbc.M310114200 }}
5. ^{{cite journal | vauthors = Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET | title = Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 46655–60 | date = Dec 2001 | pmid = 11585840 | doi = 10.1074/jbc.M108636200 }}
6. ^{{cite journal | vauthors = Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM | title = The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1 | journal = Human Molecular Genetics | volume = 11 | issue = 22 | pages = 2723–33 | date = Oct 2002 | pmid = 12374762 | pmc = 2585502 | doi = 10.1093/hmg/11.22.2723 }}

Further reading

{{cite journal | vauthors = Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET | title = Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 46655–60 | date = Dec 2001 | pmid = 11585840 | doi = 10.1074/jbc.M108636200 }}

{{cite journal | vauthors = Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM | title = The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1 | journal = Human Molecular Genetics | volume = 11 | issue = 22 | pages = 2723–33 | date = Oct 2002 | pmid = 12374762 | pmc = 2585502 | doi = 10.1093/hmg/11.22.2723 }}

{{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–903 | date = Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}

{{cite journal | vauthors = Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC | title = Human chromosome 7: DNA sequence and biology | journal = Science | volume = 300 | issue = 5620 | pages = 767–72 | date = May 2003 | pmid = 12690205 | pmc = 2882961 | doi = 10.1126/science.1083423 }}

{{cite journal | vauthors = Tanaka T, Kawashima H, Yeh ET, Kamitani T | title = Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L | journal = The Journal of Biological Chemistry | volume = 278 | issue = 35 | pages = 32905–13 | date = Aug 2003 | pmid = 12816948 | doi = 10.1074/jbc.M212057200 }}

{{cite journal | vauthors = Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA | title = Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport | journal = Experimental Cell Research | volume = 289 | issue = 2 | pages = 211–21 | date = Oct 2003 | pmid = 14499622 | doi = 10.1016/S0014-4827(03)00261-1 }}

{{cite journal | vauthors = van der Spuy J, Kim JH, Yu YS, Szel A, Luthert PJ, Clark BJ, Cheetham ME | title = The expression of the Leber congenital amaurosis protein AIPL1 coincides with rod and cone photoreceptor development | journal = Investigative Ophthalmology & Visual Science | volume = 44 | issue = 12 | pages = 5396–403 | date = Dec 2003 | pmid = 14638743 | doi = 10.1167/iovs.03-0686 }}

{{cite journal | vauthors = Hipp MS, Raasi S, Groettrup M, Schmidtke G | title = NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 16503–10 | date = Apr 2004 | pmid = 14757770 | doi = 10.1074/jbc.M310114200 }}

{{cite journal | vauthors = Tanaka T, Yeh ET, Kamitani T | title = NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis | journal = European Journal of Biochemistry / FEBS | volume = 271 | issue = 5 | pages = 972–82 | date = Mar 2004 | pmid = 15009209 | doi = 10.1111/j.1432-1033.2004.03999.x }}

{{cite journal | vauthors = Kanaya K, Sohocki MM, Kamitani T | title = Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis | journal = Biochemical and Biophysical Research Communications | volume = 317 | issue = 3 | pages = 768–73 | date = May 2004 | pmid = 15081406 | doi = 10.1016/j.bbrc.2004.03.108 }}

{{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}

{{cite journal | vauthors = van der Spuy J, Cheetham ME | title = The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments | journal = The Journal of Biological Chemistry | volume = 279 | issue = 46 | pages = 48038–47 | date = Nov 2004 | pmid = 15347646 | doi = 10.1074/jbc.M407871200 }}

{{cite journal | vauthors = Schmidtke G, Kalveram B, Weber E, Bochtler P, Lukasiak S, Hipp MS, Groettrup M | title = The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 29 | pages = 20045–54 | date = Jul 2006 | pmid = 16707496 | doi = 10.1074/jbc.M603063200 }}

{{cite journal | vauthors = Tanji K, Tanaka T, Mori F, Kito K, Takahashi H, Wakabayashi K, Kamitani T | title = NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1 | journal = The American Journal of Pathology | volume = 169 | issue = 2 | pages = 553–65 | date = Aug 2006 | pmid = 16877356 | pmc = 1698792 | doi = 10.2353/ajpath.2006.051067 }}

Function

Interactions

References

Further reading