| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.[1][2][3] Function This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3] Interactions NUP107 has been shown to interact with NUP133.[4][5] References 1. ^{{cite journal | vauthors = Boehmer T, Enninga J, Dales S, Blobel G, Zhong H | title = Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 3 | pages = 981–5 | date = Feb 2003 | pmid = 12552102 | pmc = 298712 | doi = 10.1073/pnas.252749899 }}
2. ^{{cite journal | vauthors = Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V | title = The conserved Nup107-160 complex is critical for nuclear pore complex assembly | journal = Cell | volume = 113 | issue = 2 | pages = 195–206 | date = Apr 2003 | pmid = 12705868 | pmc = | doi = 10.1016/S0092-8674(03)00235-6 }}
3. ^1 {{cite web | title = Entrez Gene: NUP107 nucleoporin 107kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57122| accessdate = }}
4. ^{{cite journal | vauthors = Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V | title = The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis | journal = Molecular Biology of the Cell | volume = 15 | issue = 7 | pages = 3333–44 | date = Jul 2004 | pmid = 15146057 | pmc = 452587 | doi = 10.1091/mbc.E03-12-0878 }}
5. ^{{cite journal | vauthors = Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V | title = An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells | journal = The Journal of Cell Biology | volume = 154 | issue = 6 | pages = 1147–60 | date = Sep 2001 | pmid = 11564755 | pmc = 2150808 | doi = 10.1083/jcb.200101081 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Bastos R, Ribas de Pouplana L, Enarson M, Bodoor K, Burke B | title = Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex | journal = The Journal of Cell Biology | volume = 137 | issue = 5 | pages = 989–1000 | date = Jun 1997 | pmid = 9166401 | pmc = 2136229 | doi = 10.1083/jcb.137.5.989 }}
- {{cite journal | vauthors = Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V | title = An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells | journal = The Journal of Cell Biology | volume = 154 | issue = 6 | pages = 1147–60 | date = Sep 2001 | pmid = 11564755 | pmc = 2150808 | doi = 10.1083/jcb.200101081 }}
- {{cite journal | vauthors = Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ | title = Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export | journal = The Journal of Cell Biology | volume = 155 | issue = 3 | pages = 339–54 | date = Oct 2001 | pmid = 11684705 | pmc = 2150853 | doi = 10.1083/jcb.200108007 }}
- {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–903 | date = Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
- {{cite journal | vauthors = Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M | title = RanGTP mediates nuclear pore complex assembly | journal = Nature | volume = 424 | issue = 6949 | pages = 689–94 | date = Aug 2003 | pmid = 12894213 | doi = 10.1038/nature01898 }}
- {{cite journal | vauthors = Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V | title = The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis | journal = Molecular Biology of the Cell | volume = 15 | issue = 7 | pages = 3333–44 | date = Jul 2004 | pmid = 15146057 | pmc = 452587 | doi = 10.1091/mbc.E03-12-0878 }}
- {{cite journal | vauthors = Krull S, Thyberg J, Björkroth B, Rackwitz HR, Cordes VC | title = Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket | journal = Molecular Biology of the Cell | volume = 15 | issue = 9 | pages = 4261–77 | date = Sep 2004 | pmid = 15229283 | pmc = 515357 | doi = 10.1091/mbc.E04-03-0165 }}
- {{cite journal | vauthors = Berke IC, Boehmer T, Blobel G, Schwartz TU | title = Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex | journal = The Journal of Cell Biology | volume = 167 | issue = 4 | pages = 591–7 | date = Nov 2004 | pmid = 15557116 | pmc = 2172596 | doi = 10.1083/jcb.200408109 }}
- {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
- {{cite journal | vauthors = Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ | title = The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly | journal = Molecular Biology of the Cell | volume = 17 | issue = 9 | pages = 3806–18 | date = Sep 2006 | pmid = 16807356 | pmc = 1593160 | doi = 10.1091/mbc.E05-11-1061 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
- {{cite journal | vauthors = Glavy JS, Krutchinsky AN, Cristea IM, Berke IC, Boehmer T, Blobel G, Chait BT | title = Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 10 | pages = 3811–6 | date = Mar 2007 | pmid = 17360435 | pmc = 1820666 | doi = 10.1073/pnas.0700058104 }}
- {{cite journal | vauthors = Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V | title = The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions | journal = The EMBO Journal | volume = 26 | issue = 7 | pages = 1853–64 | date = Apr 2007 | pmid = 17363900 | pmc = 1847668 | doi = 10.1038/sj.emboj.7601642 }}
- {{cite journal | vauthors = Boehmer T, Schwartz TU | title = Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex | journal = Acta Crystallographica Section F | volume = 63 | issue = Pt 9 | pages = 816–8 | date = Sep 2007 | pmid = 17768364 | pmc = 2376328 | doi = 10.1107/S1744309107040523 }}
{{refend}}{{Autoantigens}}{{gene-12-stub}} 1 : Nuclear pore complex |