| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Nucleoporin 133 (Nup133) is a protein that in humans is encoded by the NUP133 gene.[1][2] Function The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.[2] Interactions Nup133 has been shown to interact with NUP107.[3][4] References 1. ^{{cite journal | vauthors = Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ | title = Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export | journal = The Journal of Cell Biology | volume = 155 | issue = 3 | pages = 339–54 | date = Oct 2001 | pmid = 11684705 | pmc = 2150853 | doi = 10.1083/jcb.200108007 }}
2. ^1 {{cite web | title = Entrez Gene: NUP133 nucleoporin 133kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55746| accessdate = }}
3. ^{{cite journal | vauthors = Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V | title = The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis | journal = Molecular Biology of the Cell | volume = 15 | issue = 7 | pages = 3333–44 | date = Jul 2004 | pmid = 15146057 | pmc = 452587 | doi = 10.1091/mbc.E03-12-0878 }}
4. ^{{cite journal | vauthors = Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V | title = An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells | journal = The Journal of Cell Biology | volume = 154 | issue = 6 | pages = 1147–60 | date = Sep 2001 | pmid = 11564755 | pmc = 2150808 | doi = 10.1083/jcb.200101081 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Stoffler D, Fahrenkrog B, Aebi U | title = The nuclear pore complex: from molecular architecture to functional dynamics | journal = Current Opinion in Cell Biology | volume = 11 | issue = 3 | pages = 391–401 | date = Jun 1999 | pmid = 10395558 | doi = 10.1016/S0955-0674(99)80055-6 }}
- {{cite journal | vauthors = Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B | title = Function and assembly of nuclear pore complex proteins | journal = Biochemistry and Cell Biology | volume = 77 | issue = 4 | pages = 321–9 | year = 1999 | pmid = 10546895 | doi = 10.1139/bcb-77-4-321 }}
- {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
- {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
- {{cite journal | vauthors = Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V | title = An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells | journal = The Journal of Cell Biology | volume = 154 | issue = 6 | pages = 1147–60 | date = Sep 2001 | pmid = 11564755 | pmc = 2150808 | doi = 10.1083/jcb.200101081 }}
- {{cite journal | vauthors = Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V | title = The conserved Nup107-160 complex is critical for nuclear pore complex assembly | journal = Cell | volume = 113 | issue = 2 | pages = 195–206 | date = Apr 2003 | pmid = 12705868 | doi = 10.1016/S0092-8674(03)00235-6 }}
- {{cite journal | vauthors = Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V | title = The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis | journal = Molecular Biology of the Cell | volume = 15 | issue = 7 | pages = 3333–44 | date = Jul 2004 | pmid = 15146057 | pmc = 452587 | doi = 10.1091/mbc.E03-12-0878 }}
- {{cite journal | vauthors = Berke IC, Boehmer T, Blobel G, Schwartz TU | title = Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex | journal = The Journal of Cell Biology | volume = 167 | issue = 4 | pages = 591–7 | date = Nov 2004 | pmid = 15557116 | pmc = 2172596 | doi = 10.1083/jcb.200408109 }}
- {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
- {{cite journal | vauthors = Boehmer T, Schwartz TU | title = Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex | journal = Acta Crystallographica Section F | volume = 63 | issue = Pt 9 | pages = 816–8 | date = Sep 2007 | pmid = 17768364 | pmc = 2376328 | doi = 10.1107/S1744309107040523 }}
{{refend}}{{PDB Gallery|geneid=55746}}{{Autoantigens}}{{gene-1-stub}} 1 : Nuclear pore complex |