| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.[1][2] Function The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.[2] Interactions NUP88 has been shown to interact with NUP98.[3] References 1. ^{{cite journal | vauthors = Fornerod M, van Deursen J, van Baal S, Reynolds A, Davis D, Murti KG, Fransen J, Grosveld G | title = The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88 | journal = EMBO J. | volume = 16 | issue = 4 | pages = 807–16 | date = Mar 1997 | pmid = 9049309 | pmc = 1169681 | doi = 10.1093/emboj/16.4.807 }}
2. ^1 {{cite web | title = Entrez Gene: NUP88 nucleoporin 88kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4927| accessdate = }}
3. ^{{cite journal | vauthors = Griffis ER, Xu S, Powers MA | title = Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes | journal = Mol. Biol. Cell | volume = 14 | issue = 2 | pages = 600–10 | date = Feb 2003 | pmid = 12589057 | pmc = 149995 | doi = 10.1091/mbc.E02-09-0582 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Stoffler D, Fahrenkrog B, Aebi U | title = The nuclear pore complex: from molecular architecture to functional dynamics | journal = Curr. Opin. Cell Biol. | volume = 11 | issue = 3 | pages = 391–401 | year = 1999 | pmid = 10395558 | doi = 10.1016/S0955-0674(99)80055-6 }}
- {{cite journal | vauthors = Hood JK, Silver PA | title = Diverse nuclear transport pathways regulate cell proliferation and oncogenesis | journal = Biochim. Biophys. Acta | volume = 1471 | issue = 1 | pages = M31–41 | year = 2000 | pmid = 10967423 | doi = 10.1016/s0304-419x(00)00018-4 }}
- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G | title = Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32 | journal = Genomics | volume = 42 | issue = 3 | pages = 538–40 | year = 1997 | pmid = 9205132 | doi = 10.1006/geno.1997.4767 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Boer J, Bonten-Surtel J, Grosveld G | title = Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1236–47 | year = 1998 | pmid = 9488438 | pmc = 108836 | doi = 10.1128/mcb.18.3.1236}}
- {{cite journal | vauthors = Martínez N, Alonso A, Moragues MD, Pontón J, Schneider J | title = The nuclear pore complex protein Nup88 is overexpressed in tumor cells | journal = Cancer Res. | volume = 59 | issue = 21 | pages = 5408–11 | year = 1999 | pmid = 10554006 | doi = }}
- {{cite journal | vauthors = Gould VE, Martinez N, Orucevic A, Schneider J, Alonso A | title = A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development | journal = Am. J. Pathol. | volume = 157 | issue = 5 | pages = 1605–13 | year = 2000 | pmid = 11073820 | pmc = 1885726 | doi = 10.1016/S0002-9440(10)64798-0 }}
- {{cite journal | vauthors = Wu X, Kasper LH, Mantcheva RT, Mantchev GT, Springett MJ, van Deursen JM | title = Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 6 | pages = 3191–6 | year = 2001 | pmid = 11248054 | pmc = 30629 | doi = 10.1073/pnas.051631598 }}
- {{cite journal | vauthors = Gould VE, Orucevic A, Zentgraf H, Gattuso P, Martinez N, Alonso A | title = Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis | journal = Hum. Pathol. | volume = 33 | issue = 5 | pages = 536–44 | year = 2002 | pmid = 12094380 | doi = 10.1053/hupa.2002.124785 }}
- {{cite journal | vauthors = Griffis ER, Xu S, Powers MA | title = Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes | journal = Mol. Biol. Cell | volume = 14 | issue = 2 | pages = 600–10 | year = 2003 | pmid = 12589057 | pmc = 149995 | doi = 10.1091/mbc.E02-09-0582 }}
- {{cite journal | vauthors = Agudo D, Gómez-Esquer F, Martínez-Arribas F, Núñez-Villar MJ, Pollán M, Schneider J | title = Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer | journal = Int. J. Cancer | volume = 109 | issue = 5 | pages = 717–20 | year = 2004 | pmid = 14999780 | doi = 10.1002/ijc.20034 }}
- {{cite journal | vauthors = Schneider J, Linares R, Martínez-Arribas F, Moragues MD, Nuñez-Villar MJ, Palomar MA, Pontón J | title = Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human tumors | journal = Int. J. Dev. Biol. | volume = 48 | issue = 4 | pages = 339–42 | year = 2004 | pmid = 15300515 | doi = 10.1387/ijdb.031748js }}
- {{cite journal | vauthors = Bernad R, Engelsma D, Sanderson H, Pickersgill H, Fornerod M | title = Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export | journal = J. Biol. Chem. | volume = 281 | issue = 28 | pages = 19378–86 | year = 2006 | pmid = 16675447 | doi = 10.1074/jbc.M512585200 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
{{refend}}{{Autoantigens}}{{gene-17-stub}} 1 : Nuclear pore complex |