| 词条 | O-2172 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449583877 | IUPAC_name = methyl 2-cyclopentyl-2-(3,4-dichlorophenyl)acetate | image = O-2172_structure.png | width = 220 | tradename = | routes_of_administration = | CAS_number = | ATC_suffix = | PubChem = 11778793 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 9953475 | C=14 | H=16 | Cl=2 | O=2 | molecular_weight = 287.181 g/mol | smiles = Clc1ccc(cc1Cl)C(C(=O)OC)C2CCCC2 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C14H16Cl2O2/c1-18-14(17)13(9-4-2-3-5-9)10-6-7-11(15)12(16)8-10/h6-9,13H,2-5H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = NEHPFNBRZYFWFN-UHFFFAOYSA-N }}O-2172 is a drug developed by Organix Inc, which acts as a stimulant and potent dopamine reuptake inhibitor. It is an analogue of methylphenidate where the phenyl ring has had a 3,4-dichloro substitution added, and the piperidine ring has been replaced by cyclopentane. It is around 1/3 the potency of methylphenidate, demonstrating that even with the important binding group of the nitrogen lone pair removed entirely, selective DAT binding and reuptake inhibition is still possible.[1][2] See also
References1. ^Meltzer PC, Wang P, Blundell P, Madras BK. Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. Journal of Medicinal Chemistry. 2003 Apr 10;46(8):1538-45. {{PMID|12672255}} {{Stimulants}}{{Monoamine reuptake inhibitors}}{{nervous-system-drug-stub}}2. ^Runyon SP, Carroll FI. Dopamine transporter ligands: recent developments and therapeutic potential. Current Topics in Medicinal Chemistry. 2006;6(17):1825-43. {{PMID|17017960}} 5 : Dopamine reuptake inhibitors|Stimulants|Chloroarenes|Methyl esters|Cyclopentanes |
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