“OAZ1”的意思、由来-开放百科全书

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.^[3]

References

1. ^{{cite journal |vauthors=Tewari DS, Qian Y, Thornton RD, Pieringer J, Taub R, Mochan E, Tewari M | title = Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme | journal = Biochim Biophys Acta | volume = 1209 | issue = 2 | pages = 293–5 |date=Feb 1995 | pmid = 7811704 | pmc = | doi = 10.1016/0167-4838(94)90199-6}}
2. ^{{cite journal |vauthors=Matsufuji S, Inazawa J, Hayashi T, Miyazaki Y, Ichiba T, Furusaka A, Matsufuji T, Atkins JF, Gesteland RF, Murakami Y, Hayashi S | title = Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization | journal = Genomics | volume = 38 | issue = 1 | pages = 102–104 |date=Mar 1997 | pmid = 8954789 | pmc = | doi =10.1006/geno.1996.0601 }}
3. ^¹{{cite web | title = Entrez Gene: OAZ1 ornithine decarboxylase antizyme 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4946| accessdate = }}

Further reading

{{cite journal | author=Coffino P |title=Polyamines in spermiogenesis: not now, darling |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4421–4423 |year= 2000 |pmid= 10781034 |doi=10.1073/pnas.97.9.4421 | pmc=34313 }}

{{cite journal | author=Savage RE |title=Chloroform-induced multiple forms of ornithine decarboxylase: differential sensitivity of forms to enhancement by diethyl maleate and inhibition by ODC-antizyme |journal=Journal of toxicology and environmental health |volume=27 |issue= 1 |pages= 57–64 |year= 1989 |pmid= 2724368 |doi=10.1080/15287398909531278 |name-list-format=vanc| author2=Nofzinger K | author3=Bedell C | display-authors=3 | last4=Deangelo | first4=Anthony | last5=Pereira | first5=Michael }}

{{cite journal | author=Matsufuji S |title=Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme |journal=Cell |volume=80 |issue= 1 |pages= 51–60 |year= 1995 |pmid= 7813017 |doi=10.1016/0092-8674(95)90450-6 |name-list-format=vanc| author2=Matsufuji T | author3=Miyazaki Y | display-authors=3 | last4=Murakami | first4=Y | last5=Atkins | first5=JF | last6=Gesteland | first6=RF | last7=Hayashi | first7=S }}

{{cite journal | author=Mamroud-Kidron E |title=A unified pathway for the degradation of ornithine decarboxylase in reticulocyte lysate requires interaction with the polyamine-induced protein, ornithine decarboxylase antizyme |journal=Eur. J. Biochem. |volume=226 |issue= 2 |pages= 547–554 |year= 1995 |pmid= 8001569 |doi=10.1111/j.1432-1033.1994.tb20079.x |name-list-format=vanc| author2=Omer-Itsicovich M | author3=Bercovich Z | display-authors=3 | last4=Tobias | first4=Karin E. | last5=Rom | first5=Eran | last6=Kahana | first6=Chaim }}

{{cite journal | author=Ichiba T |title=Functional regions of ornithine decarboxylase antizyme |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 3 |pages= 1721–1727 |year= 1994 |pmid= 8185631 |doi= 10.1006/bbrc.1994.1651 |name-list-format=vanc| author2=Matsufuji S | author3=Miyazaki Y | display-authors=3 | last4=Murakami | first4=Y | last5=Tanaka | first5=K | last6=Ichihara | first6=A | last7=Hayashi | first7=S }}

{{cite journal | author=Yang D |title=Molcecular cloning of human antizyme cDNA |journal=Biochem. Mol. Biol. Int. |volume=38 |issue= 5 |pages= 957–64 |year= 1997 |pmid= 9132164 |doi= |name-list-format=vanc| author2=Takii T | author3=Hayashi H | display-authors=3 | last4=Itoh | first4=S | last5=Hayashi | first5=M | last6=Onozaki | first6=K }}

{{cite journal |vauthors=Hayashi T, Matsufuji S, Hayashi S |title=Characterization of the human antizyme gene |journal=Gene |volume=203 |issue= 2 |pages= 131–139 |year= 1998 |pmid= 9426243 |doi=10.1016/S0378-1119(97)00504-0 }}

{{cite journal |vauthors=Zhu C, Lang DW, Coffino P |title=Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport |journal=J. Biol. Chem. |volume=274 |issue= 37 |pages= 26425–26430 |year= 1999 |pmid= 10473601 |doi=10.1074/jbc.274.37.26425 }}

{{cite journal |vauthors=Chen H, MacDonald A, Coffino P |title=Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 45957–45961 |year= 2003 |pmid= 12359729 |doi= 10.1074/jbc.M206799200 }}

{{cite journal | author=Ike A |title=Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3) |journal=Gene |volume=298 |issue= 2 |pages= 183–193 |year= 2003 |pmid= 12426106 |doi=10.1016/S0378-1119(02)00978-2 |name-list-format=vanc| author2=Yamada S | author3=Tanaka H | display-authors=3 | last4=Nishimune | first4=Y | last5=Nozaki | first5=M }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Grimwood J |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–535 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |name-list-format=vanc| author2=Gordon LA | author3=Olsen A | display-authors=3 | last4=Terry | first4=Astrid | last5=Schmutz | first5=Jeremy | last6=Lamerdin | first6=Jane | last7=Hellsten | first7=Uffe | last8=Goodstein | first8=David | last9=Couronne | first9=Olivier }}

{{cite journal |vauthors=Mangold U, Leberer E |title=Regulation of all members of the antizyme family by antizyme inhibitor |journal=Biochem. J. |volume=385 |issue= Pt 1 |pages= 21–8 |year= 2005 |pmid= 15355308 |doi= 10.1042/BJ20040547 | pmc=1134669 }}

{{cite journal | author=Choi KS |title=Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 206–212 |year= 2005 |pmid= 15670771 |doi= 10.1016/j.bbrc.2004.11.172 |name-list-format=vanc| author2=Suh YH | author3=Kim WH | display-authors=3 | last4=Lee | first4=T | last5=Jung | first5=M }}

{{cite journal | author=Ku M |title=OAZ regulates bone morphogenetic protein signaling through Smad6 activation |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 5277–5287 |year= 2006 |pmid= 16373339 |doi= 10.1074/jbc.M510004200 |name-list-format=vanc| author2=Howard S | author3=Ni W | display-authors=3 | last4=Lagna | first4=G | last5=Hata | first5=A }}

{{cite journal | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–814 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-format=vanc| author2=Hao T | author3=Shaw C | display-authors=3 | last4=Patel | first4=Akash J. | last5=Szabó | first5=Gábor | last6=Rual | first6=Jean-François | last7=Fisk | first7=C. Joseph | last8=Li | first8=Ning | last9=Smolyar | first9=Alex }}

{{cite journal | author=Tsuji T |title=Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells |journal=Biochemistry |volume=46 |issue= 31 |pages= 8920–8932 |year= 2007 |pmid= 17630775 |doi= 10.1021/bi7000328 |name-list-format=vanc| author2=Katsurano M | author3=Ibaragi S | display-authors=3 | last4=Shima | first4=Kaori | last5=Sasaki | first5=Akira | last6=Hu | first6=Guo-fu }}