| 词条 | Onchidal |
| 释义 |
| Watchedfields = changed | verifiedrevid = 445022070 | IUPAC_name = (1E,3E)-5-(2,2-Dimethyl-6-methylenecyclohexyl)-3-formylpenta-1,3-dien-1-yl acetate | image = Onchidal.png | width = 240 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 67656-42-2 | ATC_prefix = none | ATC_suffix = | PubChem = 6441116 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4945331 | C=17 | H=24 | O=3 | molecular_weight = 276.371 g/mol | smiles = CC(=O)O\\C=C\\C(=C/CC1C(=C)CCCC1(C)C)\\C=O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H24O3/c1-13-6-5-10-17(3,4)16(13)8-7-15(12-18)9-11-20-14(2)19/h7,9,11-12,16H,1,5-6,8,10H2,2-4H3/b11-9+,15-7+ | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = BEKQPDFPPJFVJP-AHSQCEKMSA-N }}Onchidal is a naturally occurring toxin produced as a defensive secretion by the mollusc Onchidella binneyi and several other related species in Onchidella,a genus of small, air-breathing sea slugs. It acts as an irreversible acetylcholinesterase inhibitor, the same mechanism of action as that of the deadly nerve agents, however onchidal is not an organophosphorus or carbamate compound and bears little resemblance to other compounds of this nature.[1] References1. ^Abramson SN, Radic Z, Manker D, Faulkner DJ, Taylor P. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Molecular Pharmacology. 1989 Sep;36(3):349-54. {{PMID|2779521}} {{Toxins}}{{Acetylcholine metabolism and transport modulators}}{{pharmacology-stub}} 6 : Acetylcholinesterase inhibitors|Invertebrate toxins|Aldehydes|Alkene derivatives|Sesquiterpenes|Acetate esters |
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