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词条 ORC4
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.[1][2][3]

Function

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.[3]

Interactions

ORC4 has been shown to interact with:

{{div col|colwidth=20em}}
  • MCM2,[5]
  • MCM3,[5]
  • MCM4,[5]
  • MCM6,[5]
  • ORC1,[4]
  • ORC2,[1][4][5][6]
  • ORC3,[5][6][7]
  • ORC5,[4][5][8] and
  • ORC6.[4]
{{Div col end}}

References

1. ^1 {{cite journal | vauthors = Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A | title = Identification of HsORC4, a member of the human origin of replication recognition complex | journal = The Journal of Biological Chemistry | volume = 272 | issue = 45 | pages = 28247–51 | date = Nov 1997 | pmid = 9353276 | pmc = | doi = 10.1074/jbc.272.45.28247 }}
2. ^{{cite journal | vauthors = Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F | title = Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis | journal = Cytogenetics and Cell Genetics | volume = 81 | issue = 1 | pages = 89–90 | date = October 1998 | pmid = 9691185 | pmc = | doi = 10.1159/000014997 }}
3. ^1 {{cite web | title = Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5000| accessdate = }}
4. ^1 2 3 4 5 6 7 {{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = Journal of Molecular Biology | volume = 327 | issue = 1 | pages = 111–28 | date = Mar 2003 | pmid = 12614612 | doi = 10.1016/s0022-2836(03)00079-2}}
5. ^1 2 {{cite journal | vauthors = Dhar SK, Delmolino L, Dutta A | title = Architecture of the human origin recognition complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29067–71 | date = Aug 2001 | pmid = 11395502 | doi = 10.1074/jbc.M103078200 }}
6. ^1 {{cite journal | vauthors = Vashee S, Simancek P, Challberg MD, Kelly TJ | title = Assembly of the human origin recognition complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 28 | pages = 26666–73 | date = Jul 2001 | pmid = 11323433 | doi = 10.1074/jbc.M102493200 }}
7. ^{{cite journal | vauthors = Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A | title = latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant | journal = Neuron | volume = 23 | issue = 1 | pages = 45–54 | date = May 1999 | pmid = 10402192 | doi = 10.1016/s0896-6273(00)80752-7}}
8. ^{{cite journal | vauthors = Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A | title = ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27137–45 | date = Oct 1998 | pmid = 9765232 | doi = 10.1074/jbc.273.42.27137}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B | title = The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 32421–9 | date = Dec 1998 | pmid = 9829972 | doi = 10.1074/jbc.273.49.32421 }}
  • {{cite journal | vauthors = Springer J, Kneissl M, Pütter V, Grummt F | title = Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex | journal = Chromosoma | volume = 108 | issue = 4 | pages = 243–9 | date = Aug 1999 | pmid = 10460412 | doi = 10.1007/s004120050374 }}
  • {{cite journal | vauthors = Jiang W, McDonald D, Hope TJ, Hunter T | title = Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5703–13 | date = Oct 1999 | pmid = 10523313 | pmc = 1171637 | doi = 10.1093/emboj/18.20.5703 }}
  • {{cite journal | vauthors = Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A | title = Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 35233–41 | date = Nov 2000 | pmid = 10954718 | doi = 10.1074/jbc.M005765200 }}
  • {{cite journal | vauthors = Vashee S, Simancek P, Challberg MD, Kelly TJ | title = Assembly of the human origin recognition complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 28 | pages = 26666–73 | date = Jul 2001 | pmid = 11323433 | doi = 10.1074/jbc.M102493200 }}
  • {{cite journal | vauthors = Dhar SK, Delmolino L, Dutta A | title = Architecture of the human origin recognition complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29067–71 | date = Aug 2001 | pmid = 11395502 | doi = 10.1074/jbc.M103078200 }}
  • {{cite journal | vauthors = Okuno Y, McNairn AJ, den Elzen N, Pines J, Gilbert DM | title = Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle | journal = The EMBO Journal | volume = 20 | issue = 15 | pages = 4263–77 | date = Aug 2001 | pmid = 11483529 | pmc = 149150 | doi = 10.1093/emboj/20.15.4263 }}
  • {{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = Journal of Molecular Biology | volume = 327 | issue = 1 | pages = 111–28 | date = Mar 2003 | pmid = 12614612 | doi = 10.1016/S0022-2836(03)00079-2 }}
  • {{cite journal | vauthors = Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J | title = Self-assembling protein microarrays | journal = Science | volume = 305 | issue = 5680 | pages = 86–90 | date = Jul 2004 | pmid = 15232106 | doi = 10.1126/science.1097639 }}
  • {{cite journal | vauthors = Sibani S, Price GB, Zannis-Hadjopoulos M | title = Ku80 binds to human replication origins prior to the assembly of the ORC complex | journal = Biochemistry | volume = 44 | issue = 21 | pages = 7885–96 | date = May 2005 | pmid = 15910003 | doi = 10.1021/bi047327n }}
  • {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
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