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词条 OS9 (gene)
释义

  1. Function

  2. Model organisms

  3. References

  4. Further reading

{{Infobox_gene}}Protein OS-9 is a protein that in humans is encoded by the OS9 gene.[1][2][3][4][5]

Function

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

Model organisms

Model organisms have been used in the study of OS9 function. A conditional knockout mouse line called Os9tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12]{{clear|left}}

References

1. ^{{cite journal | vauthors = Su YA, Hutter CM, Trent JM, Meltzer PS | title = Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas | journal = Molecular Carcinogenesis | volume = 15 | issue = 4 | pages = 270–5 | date = Apr 1996 | pmid = 8634085 | pmc = | doi = 10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K }}
2. ^{{cite journal | vauthors = Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M | title = Genomic organization of the OS-9 gene amplified in human sarcomas | journal = Journal of Biochemistry | volume = 122 | issue = 6 | pages = 1190–5 | date = Dec 1997 | pmid = 9498564 | pmc = | doi = 10.1093/oxfordjournals.jbchem.a021880 }}
3. ^{{cite journal | vauthors = Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K | title = Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans | journal = The Journal of Biological Chemistry | volume = 284 | issue = 25 | pages = 17061–8 | date = Jun 2009 | pmid = 19346256 | pmc = 2719344 | doi = 10.1074/jbc.M809725200 }}
4. ^{{cite journal | vauthors = Christianson JC, Shaler TA, Tyler RE, Kopito RR | title = OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD | journal = Nature Cell Biology | volume = 10 | issue = 3 | pages = 272–82 | date = Mar 2008 | pmid = 18264092 | pmc = 2757077 | doi = 10.1038/ncb1689 }}
5. ^1 {{cite web | title = Entrez Gene: OS9 amplified in osteosarcoma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10956| accessdate = }}
6. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
7. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Os9#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
8. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
9. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
10. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
11. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}
12. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Os9&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL | title = OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha | journal = Molecular Cell | volume = 17 | issue = 4 | pages = 503–12 | date = Feb 2005 | pmid = 15721254 | doi = 10.1016/j.molcel.2005.01.011 }}
  • {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
  • {{cite journal | vauthors = Vigneron N, Ooms A, Morel S, Degiovanni G, Van Den Eynde BJ | title = Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma | journal = Cancer Immunity | volume = 2 | issue = | pages = 9 | date = Jul 2002 | pmid = 12747754 | doi = }}
  • {{cite journal | vauthors = Litovchick L, Friedmann E, Shaltiel S | title = A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 34413–23 | date = Sep 2002 | pmid = 12093806 | doi = 10.1074/jbc.M203986200 }}
  • {{cite journal | vauthors = Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst JE | title = YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 38 | pages = 35274–81 | date = Sep 2002 | pmid = 12077121 | doi = 10.1074/jbc.M201044200 }}
  • {{cite journal | vauthors = Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T | title = Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma | journal = FEBS Letters | volume = 453 | issue = 1-2 | pages = 77–80 | date = Jun 1999 | pmid = 10403379 | doi = 10.1016/S0014-5793(99)00700-0 }}
  • {{cite journal | vauthors = Kimura Y, Nakazawa M, Yamada M | title = Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines | journal = Journal of Biochemistry | volume = 123 | issue = 5 | pages = 876–82 | date = May 1998 | pmid = 9562620 | doi = 10.1093/oxfordjournals.jbchem.a022019 }}
  • {{cite journal | vauthors = Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS | title = Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers | journal = Genomics | volume = 42 | issue = 2 | pages = 295–301 | date = Jun 1997 | pmid = 9192850 | doi = 10.1006/geno.1997.4727 }}
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2 : Proteins|Genes
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