| 释义 |
- References
- Further reading
{{Infobox_gene}}Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.[1][2][3][4]{{PBB_Summary
| section_title =
| summary_text = Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.[4]
}}References1. ^{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP| title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 |date=Dec 1999 | pmid = 10591208 | pmc = | doi = 10.1038/990031 |display-authors=etal}}
2. ^{{cite journal | vauthors = Moreira EF, Jaworski C, Li A, Rodriguez IR | title = Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina | journal = J Biol Chem | volume = 276 | issue = 21 | pages = 18570–8 |date=May 2001 | pmid = 11278871 | pmc = | doi = 10.1074/jbc.M011259200 }}
3. ^{{cite journal | vauthors = Wang C, JeBailey L, Ridgway ND | title = Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments | journal = Biochem J | volume = 361 | issue = Pt 3 | pages = 461–72 |date=Jan 2002 | pmid = 11802775 | pmc = 1222328 | doi =10.1042/0264-6021:3610461 }}
4. ^1 {{cite web | title = Entrez Gene: OSBP2 oxysterol binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23762| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Hirosawa M, Nagase T, Murahashi Y, etal |title=Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping |journal=DNA Res. |volume=8 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11258795 |doi=10.1093/dnares/8.1.1 }}
- {{cite journal |vauthors=Lehto M, Laitinen S, Chinetti G, etal |title=The OSBP-related protein family in humans |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1203–13 |year= 2001 |pmid= 11483621 |doi= }}
- {{cite journal |vauthors=Jaworski CJ, Moreira E, Li A, etal |title=A family of 12 human genes containing oxysterol-binding domains |journal=Genomics |volume=78 |issue= 3 |pages= 185–96 |year= 2002 |pmid= 11735225 |doi= 10.1006/geno.2001.6663 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Henriques Silva N, Vasconcellos Fournier M, Pimenta G, etal |title=HLM/OSBP2 is expressed in chronic myeloid leukemia |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 663–6 |year= 2004 |pmid= 12964051 |doi= 10.3892/ijmm.12.4.663}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal | vauthors=Wyles JP, Perry RJ, Ridgway ND |title=Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization |journal=Exp. Cell Res. |volume=313 |issue= 7 |pages= 1426–37 |year= 2007 |pmid= 17350617 |doi= 10.1016/j.yexcr.2007.01.018 }}
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