| 释义 |
- References
- Further reading
{{Infobox_gene}}Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]
}}References1. ^{{cite journal | vauthors = Kim N, Takami M, Rho J, Josien R, Choi Y | title = A novel member of the leukocyte receptor complex regulates osteoclast differentiation | journal = J Exp Med | volume = 195 | issue = 2 | pages = 201–9 |date=Jan 2002 | pmid = 11805147 | pmc = 2193610 | doi = 10.1084/jem.20011681 }}
2. ^{{cite web | title = Entrez Gene: OSCAR osteoclast-associated receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126014| accessdate = }}
3. ^{{cite web | title = Entrez Gene: OSCAR osteoclast-associated receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126014| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Pupello DF, Lipton M, Shumway NE |title=An unusual case of a bullet embolus. |journal=The Journal of the Florida Medical Association |volume=62 |issue= 11 |pages= 51 |year= 1976 |pmid= 1185147 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Merck E, Gaillard C, Gorman DM, etal |title=OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. |journal=Blood |volume=104 |issue= 5 |pages= 1386–95 |year= 2004 |pmid= 15155468 |doi= 10.1182/blood-2004-03-0850 }}
- {{cite journal |vauthors=Merck E, de Saint-Vis B, Scuiller M, etal |title=Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses. |journal=Blood |volume=105 |issue= 9 |pages= 3623–32 |year= 2005 |pmid= 15650060 |doi= 10.1182/blood-2004-07-2809 }}
- {{cite journal |vauthors=Tenca C, Merlo A, Merck E, etal |title=CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells. |journal=J. Immunol. |volume=174 |issue= 11 |pages= 6757–63 |year= 2005 |pmid= 15905516 |doi= 10.4049/jimmunol.174.11.6757}}
- {{cite journal |vauthors=Kim GS, Koh JM, Chang JS, etal |title=Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. |journal=J. Bone Miner. Res. |volume=20 |issue= 8 |pages= 1342–8 |year= 2005 |pmid= 16007331 |doi= 10.1359/JBMR.050320 }}
- {{cite journal |vauthors=Kim K, Kim JH, Lee J, etal |title=Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35209–16 |year= 2005 |pmid= 16109714 |doi= 10.1074/jbc.M505815200 }}
- {{cite journal |vauthors=Merck E, Gaillard C, Scuiller M, etal |title=Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils. |journal=J. Immunol. |volume=176 |issue= 5 |pages= 3149–56 |year= 2006 |pmid= 16493074 |doi= 10.4049/jimmunol.176.5.3149}}
{{refend}}{{gene-19-stub}} |