| 词条 | Oxadiazole | ||||
| 释义 |
Oxadiazoles are a class of heterocyclic aromatic chemical compound of the azole family; with the molecular formula C2H2N2O. There are four isomers of oxadiazole: 1,2,4-Oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole are all known and appear in a variety of pharmaceutical drugs including raltegravir, butalamine, fasiplon, oxolamine, and pleconaril. The 1,2,3-isomer is unstable and ring-opens to form the diazoketone tautomer,[1] however it does exist within the unusual sydnone motif. In 2018, a compound called bis(1,2,4-oxadiazole)bis(methylene) dinitrate which might have a 1.5 times the power of TNT was developed at the United States Army Research Laboratory (ARL) working with the Los Alamos National Laboratory.[2] References1. ^{{cite book|author1=John A. Joule|author2=Keith Mills|title=Heterocyclic Chemistry|url=https://books.google.com/books?id=SREl8qmp37MC&pg=PT842|date=28 May 2013|publisher=John Wiley & Sons|isbn=1-118-68164-9|pages=842}} {{heterocyclic-stub}}2. ^{{cite web|url=https://cen.acs.org/materials/Double-oxadiazole-replace-TNT/96/web/2018/06|title=Double oxadiazole could replace TNT|work=c&en|date=5 June 2018}} 1 : Oxadiazoles |
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