| 词条 | Oxetorone |
| 释义 |
| verifiedrevid = 444750715 | IUPAC_name = (3Z)-3-[1]benzofuro[3,2-c][1]benzoxepin-6(12H)-ylidene-N,N-dimethylpropan-1-amine | image = Oxetorone.png | width = 180 | alt = Skeletal formula of oxetorone | image2 = Oxetorone-3D-spacefill.png | alt2 = Space-filling model of the oxetorone molecule | tradename = | Drugs.com = {{drugs.com|international|oxetorone}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 26020-55-3 | ATC_prefix = N02 | ATC_suffix = CX06 | PubChem = 6436540 | ChemSpiderID = 21173074 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = T3XOS33TIQ | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D08312 | chemical_formula = | C=21 | H=21 | N=1 | O=2 | molecular_weight = 319.40 g/mol | smiles = CN(C)CCC=C1C2=CC=CC=C2OCC3=C1OC4=CC=CC=C34 | StdInChI = 1S/C21H21NO2/c1-22(2)13-7-10-17-15-8-3-5-11-19(15)23-14-18-16-9-4-6-12-20(16)24-21(17)18/h3-6,8-12H,7,13-14H2,1-2H3 | StdInChIKey = VZVRZTZPHOHSCK-UHFFFAOYSA-N }}Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug.[1][2][3][4] Association with hyperprolactinemia has been described.[5] References1. ^{{cite book|author1=C.R. Ganellin|author2=David J. Triggle|title=Dictionary of Pharmacological Agents|url=https://books.google.com/books?id=A0THacd46ZsC&pg=PA1493|date=21 November 1996|publisher=CRC Press|isbn=978-0-412-46630-4|pages=1493–}} {{Antimigraine preparations}}{{Adrenergics}}{{Histaminergics}}{{Serotonergics}}{{Tricyclics}}{{analgesic-stub}}2. ^{{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition|url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA2935-IA131|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=2935–}} 3. ^{{cite book|author1=C.J. van Boxtel|author2=B. Santoso|author3=I.R. Edwards|title=Drug Benefits and Risks: International Textbook of Clinical Pharmacology - Revised 2nd Edition|url=https://books.google.com/books?id=idbvAgAAQBAJ&pg=PA699|date=6 August 2008|publisher=IOS Press|isbn=978-1-60750-345-3|pages=699–}} 4. ^{{cite journal |author=Massiou H |title=[Prophylactic treatments of migraine] |language=French |journal=Rev. Neurol. (Paris) |volume=156 Suppl 4 |issue= |pages=4S79–86 |year=2000 |pmid=11139754 |doi= |url=http://www.masson.fr/masson/79997}} 5. ^{{cite journal |author=Pradalier A |title=Hyperprolactinaemia and depression induced by oxetorone |journal=Cephalalgia |volume=16 |issue=8 |pages=560–1 |date=December 1996 |pmid=8980859 |doi= 10.1046/j.1468-2982.1996.1608560.x|url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0333-1024&date=1996&volume=16&issue=8&spage=560|archive-url=https://archive.today/20130105095757/http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0333-1024&date=1996&volume=16&issue=8&spage=560|dead-url=yes|archive-date=2013-01-05}} 6 : Antimigraine drugs|Alpha blockers|H1 receptor antagonists|Serotonin antagonists|Oxygen heterocycles|Heterocyclic compounds (4 or more rings) |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。