| 词条 | Oxipurinol |
| 释义 |
| ImageFile = Oxypurinol.svg | PIN = 1,2-Dihydropyrazolo[4,3-e]pyrimidine-4,6-dione | SystematicName = 1H,2H,4H,5H,6H-pyrazolo[3,4-d]pyrimidine-4,6-dione | OtherNames = 1H,2H,5H-pyrazolo[3,4-d]pyrimidine-4,6-dione Alloxanthine |Section1={{Chembox Identifiers | CASNo = 2465-59-0 | PubChem = 4644 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 859 | ChemSpiderID = 4483 | EINECS = 219-570-9 | KEGG = C07599 | MeSHName = Oxypurinol | ChEBI = 28315 | UNII = G97OZE5068 | SMILES = O=C1NC(=O)C2=CNNC2=N1 | InChI = 1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11) | InChIKey = HXNFUBHNUDHIGC-UHFFFAOYSA-N | Beilstein = 139956}} |Section2={{Chembox Properties | Formula=C5H4N4O2 | MolarMass=152.11086 | Appearance=white crystals | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }} Oxipurinol (INN, or oxypurinol USAN) is an inhibitor of xanthine oxidase.[1] It is an active metabolite of allopurinol and it is cleared renally.[2] In cases of renal disease, this metabolite will accumulate to toxic levels. By inhibiting xanthine oxidase, it reduces uric acid production. High serum uric acid levels may result in gout, kidney stones, and other medical conditions. References1. ^{{cite journal|title=The pharmacokinetics of oxypurinol in people with gout|journal=British Journal of Clinical Pharmacology|volume=74|issue=3|pages=477–489|doi=10.1111/j.1365-2125.2012.04207.x|pmid=22300439|pmc=3477349|year=2012|last1=Stocker|first1=Sophie L|last2=McLachlan|first2=Andrew J|last3=Savic|first3=Radojka M|last4=Kirkpatrick|first4=Carl M|last5=Graham|first5=Garry G|last6=Williams|first6=Kenneth M|last7=Day|first7=Richard O}} {{Purinergics}}{{Authority control}}{{heterocyclic-stub}}2. ^{{cite journal|title=Renal clearance of oxipurinol, the chief metabolite of allopurinol|journal=The American Journal of Medicine|volume=45|issue=1|pages=69–77|doi=10.1016/0002-9343(68)90008-9|pmid=5658870|year=1968|last1=Elion|first1=Gertrude B|last2=Yü|first2=Ts'ai-Fan|last3=Gutman|first3=Alexander B|last4=Hitchings|first4=George H}} 3 : Pyrazolopyrimidines|Xanthine oxidase inhibitors|Human drug metabolites |
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