P108, P-108, or P.108 may refer to:
- P108, a highway in Latvia; see List of National Roads in Latvia#State Regional Roads
108, a designation for Papyrus 108, an early copy of the New Testament in Greek- Piaggio P.108, an Italian heavy bomber of 1942-1945
- P.108 Balliol T.Mk 1 by Boulton Paul Aircraft
- 1968 in spaceflight
- 1968 Intercontinental Cup
- 1968 in the UK
- 1968 in the United Kingdom
- 1968 Invasion of Czechoslovakia
- 1968 in Wales
- 1968 in Zimbabwe
- 1968 Irish constitutional referendums
- 1968 Isle of Man TT
- 1968 Israeli raid on Lebanon
- 1968 Italian general election
- 1968 Kansas City Chiefs season
- 1968 Liberal Party of Canada leadership convention
- 1968 Little League World Series
- 1968 Los Angeles Dodgers season
- 1968 Los Angeles Rams season
- 1968 Louisville riots
- 1968 Luxembourg general election
- 1968 Masters Tournament
- 1968 Memorial Cup
- 1968 Mexico City Olympic Games
- 1968 Minnesota Twins
- 1968 Minnesota Twins season
- 1968 Minnesota Vikings season
- 1968 movies