“P24 capsid protein”的意思、由来-开放百科全书

词条

P24 capsid protein

释义

Fourth generation HIV test
References

p24 is a component of the HIV particle capsid. There are approximately 2000 molecules per virus particle, or at a molecule weight of 24 kDa, about 10⁴ virus particles per picogram of p24. The onset of symptoms of AIDS correlates with a reduction in the number of CD4+ T-cells and increased levels of virus and p24 in the blood.^[1]

Fourth generation HIV test

Fourth-generation HIV immunoassays detect viral p24 protein in the blood (as well as patient antibodies against the virus). Previous generation tests relied on detecting patient antibodies alone; it takes about 3–4 weeks for the earliest antibodies to be detected. The p24 protein can be detected in patient blood as early as 2 weeks after HIV infection, further reducing the window period necessary to accurately detect the HIV status of the patient.^[2]

References

http://tronolab.epfl.ch/webdav/site/tronolab/shared/protocols/TUvsp24.html
http://capitolregiontelehealth.org/documents/AETC-Webinar-2.pdf

1. ^Medical Microbiology, p637
2. ^http://hivinsite.ucsf.edu/InSite.jsp?page=kb-02-02-01

{{protein-stub}}Virus de l'immunodéficience humaine#Structure

2 : Viral proteins|HIV/AIDS

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